摘要
目的:检测M_2受体自身抗体在重度子痫前期患者中的表达,探讨其临床意义。方法:选择2013年1月至2015年1月在首都医科大学附属朝阳医院妇产科收治的78例重度子痫前期孕妇为研究对象,并取同期收治的78例正常单胎足月孕妇和60例未妊娠妇女作为对照。采用ELISA方法检测3组妇女血浆中的M_2受体自身抗体水平,并分析其在重度子痫前期中的临床意义。结果:重度子痫患者M_2受体自身抗体阳性率32.1%(25/78),正常妊娠组为10.3%(8/78),两组阳性率比较差异有统计学意义(P<0.01);未妊娠组阳性率8.3%(5/60),与正常妊娠组比较差异无统计学意义(P>0.05);此外,重度子痫前期患者血清中肌酸激酶浓度为(101.49±142.75)U/L,而正常妊娠组肌酸激酶含量为(57.94.±31.64)U/L,两组比较差异有统计学意义(P<0.05)。结论:M_2受体自身抗体在重度子痫前期患者中的表达明显增高,可能与其发病有关。
Objective： To test the expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia. Methods： A case-control study3 including 78 patients with severe preeclampsia and 78 women with normal pregnancy in Department of Gynaecology and Obstetrics of Capital Medical University affiliated Beijing Chao-Yang Hospital from Jan, 2013 to Jan, 2015, were conducted, and 60 non-pregnant women were served as a control group. ELISA protocol was used to test serum autoantibody against the M2-muscarinic receptor. The clinical significance of the autoantibody against the M2-muscarinic receptor among women with severe preeclampsia was estimated. Results： Autoantibody against the M2-muscarinic receptor were positive in 32.1% （25/78） of patients with severe preeclampsia, in 10.3% （8/78, P〈0.05） of normal pregnant women and in 8.3%（5/60, P〈0.05） of non-pregnant controls. The concentration of creatine kinase in patients with severe preedampsia and normal pregnant women were （101.49±142.75） and （57.94±31.64） U/L, respectively. Mask difference exist between the severe preeclampsia group and the normal pregnancy group （P〈0.05）. Conclusion： The expression of autoantibody against the M2-muscarinic receptor in patients with severe preedampsia is elevated significantly, which is associated with severe preeclampsia. However, its etiological role needs further to be investigated.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2016年第7期707-710,共4页
Journal of Central South University ：Medical Science
关键词
重度子痫前期
妊娠
M2受体
自身抗体
severe preeclampsia
pregnancy
M2-muscarinic receptor
autoantibody
