摘要
目的:系统评价人S100B蛋白与新生儿脑损伤的关系。方法:以"S100B、新生儿、脑损伤"为检索词,联合检索中国知网期刊全文数据库和万方数据库,以"S100B、neonate、brain injury"为检索词,联合检索Cochrane图书馆、PubMed、EMBASE、Web of Science,时间跨度均从建库至2016-03,获得新生儿脑损伤对生物体液中S100B蛋白水平影响相关的文献,并对纳入文献进行资料摄取和质量评价。采用Cochrane图书馆Rev Man 5.2软件对文献进行Meta分析。结果:共检索196篇文献,最后纳入19篇,其中有14篇与新生儿缺氧缺血性脑病(HIE)有关,2篇与围产期其它危险因素(宫内发育迟缓、脐动脉异常)所致的新生儿脑损伤有关,3篇与足月儿高胆红素血症所致脑损伤有关。高质量文献(NOS≥7分)17篇,余2篇NOS为5分。Meta分析HIE致脑损伤新生儿血液和尿液S100B蛋白水平较对照组升高,均数差(MD)分别为0.71和0.73(95%CI:0.52-0.90、0.07-1.39);围产期其它危险因素所致脑损伤新生儿脐带血S100B蛋白水平较对照组升高,MD=2.15(95%CI:1.72-2.59);足月儿高胆红素血症致脑损伤新生儿S100B蛋白水平亦较对照组升高,MD=1.42(95%CI:1.03-1.81)。11篇HIE致脑损伤研究存在文献发表偏倚。结论:新生儿几种生物体液中S100B蛋白水平升高对其脑损伤可能有早期提示作用。
Objective：To systematic evaluate the relationship of S100 Bprotein and neonatal brain injury.Method：Obtained the documents about the effect of neonatal brain injury on S100 Bprotein level in biological fluids by searching the Cochrane library,PubMed,EMBASE,Web of Science,CNKI and WanFang Database（from building a datebase to March 2016）with the index words of S100 B,neonate and brain injury.Evaluated the quality of the included studies and absorb the information one by one.Then the meta-analysis was performed by review manager version 5.2.Results：A total of 196 documents retrieved for the evaluation,19 of the literatures could be included into the Meta-analysis including 14 articles related to hypoxic-ischemic encephalopathy（HIE）,2articles related to perinatal risk factors（intrauterine growth retardation,abnormal umbilical artery）,3articles related to bilirubin-induced neurotoxicity in term neonates.There were 17high-quality literature（NOS≥7points）.The remainig 2documents NOS score is 5points.There was a significant difference of S100 Bprotein level in blood of neonates with brain injury caused by HIE,S100 Bprotein combined MD=0.71（95% CI：0.52-0.90）.There was a significant difference of S100 Bprotein level in urine of neonates with brain injury caused by HIE,S100 Bprotein combined MD=0.73（95%CI：0.07-1.39）.There was a significant difference of S100 Bprotein level in the brain injury caused by perinatal risk factors（intrauterine growth retardation,abnormal umbilical artery）,S100 Bprotein combined MD=2.15（95%CI：1.72-2.59）.There was a significant difference of S100 Bprotein level in term neonates with brain injury caused by hyperbilirubinemia,S100 Bprotein combined MD=1.42（95% CI：1.03-1.81）.There exist publication bias in the 11 literature about brain damage caused by HIE.Conclusion：Neonatal brain injury caused by HIE,perinatal risk factors（intrauterine growth retardation,abnormal umbilical artery）and hyperbilirubinemia will increase S100 Bprotein levels in blood,urine and cord blood.The detection of S100 Bprotein may play a role in the diagnosis of neonatal brain injury.
出处
《微循环学杂志》
2016年第3期41-46,共6页
Chinese Journal of Microcirculation
基金
国家自然科学基金(81471337)
江苏省卫计委课题(RC2011113)
