摘要
目的研究分析帕瑞昔布钠与下肢神经阻滞联用对膝关节和远端手术患者的镇痛效果。方法从2010年3月-2013年3月,于我院132例需行膝关节和远端手术患者,经我院医学伦理委员会批准后,按照随机数字表法将患者分为观察组（66例）和对照组（66例）。对照组采取下肢神经阻滞进行麻醉,观察组采用帕瑞昔布钠与下肢神经阻滞联合麻醉。观察两组患者术后的疼痛评分以及不良反应情况。结果观察组术后24h,48h以及72h的VAS评分均显著低于对照组,观察组首次出现疼痛感觉时间显著高于对照组,要求使用镇痛药物例数以及吗啡用量显著低于对照组（P〈0.05）,两组在皮肤瘙痒以及头晕发热发生率方面差异无统计学意义,但观察组恶心呕吐发生率显著低于对照组,差异有统计学意义（P〈0.05）。结论帕瑞昔布钠与下肢神经阻滞联用对膝关节和远端手术患者,不仅镇痛效果好,还能显著降低不良反应的发生率,值得推广。
Objective To research and analyze the analgesic effect of parecoxib sodium combined with lower extremity nerve block on knee joint and distal surgical patients. Methods 132 patients with knee joint and distal surgery from March 2010 to March 2013 in my hospital were randomly divided into 66 cases of observation group and 66 cases of control group in accordance with digital table method,after the approval of the medical ethics committee in my hospital.The control group received anaesthesia of lower extremity nerve block,while the observation group received anaesthesia of parecoxib sodium combined with lower extremity nerve block.The postoperative pain score and adverse reactions of the two groups were observed. Results In the observation group,the VAS scores of postoperative 24 h,48h and 72 h were all significantly lower than that of the control group,first pain sensation time was dramatically higher than that of the control group,the number of cases required to utilize analgesic drugs and dosage of morphine were significantly lower than that of the control group（P〈0.05）,the differences in skin pruritus and incidence rate of dizziness and fever between the two groups had no statistical significance,but the incidence rate of nausea and vomiting was dramatically lower than that of the control group,the difference had statistical significance（P〈0.05）. Conclusion The parecoxib sodium combined with lower extremity nerve block on knee joint and distal surgical patients not only had good analgesic effect,but also significantly decreased the incidence rate of adverse reactions,which was worthy of promotion.
出处
《中国医药科学》
2016年第13期149-151,共3页
China Medicine And Pharmacy
关键词
帕瑞昔布钠
下肢神经阻滞
膝关节
远端手术
镇痛效果
Parecoxib sodium
Lower extremity nerve block
Knee joint
Distal surgery
Analgesic effect
