摘要
目的:探讨肺癌脑转移瘤使用单纯全脑放疗与联合γ-刀局部加量放疗的临床疗效差异。方法:选择60名肺癌脑转移患者,随机分为A、B 2组,每组30人,A组接受全脑照射治疗,B组接受全脑照射治疗后行γ-刀局部加量治疗。对比2组患者颅内肿瘤缩小程度、客观缓解率、总生存期。结果:A组患者颅内肿瘤缩小程度小于B组患者(P<0.05);A组患者客观缓解率小于B组患者(P<0.05);A组患者较B组患者总生存期短,且存在明显差异(P<0.05)。结论:全脑放疗可提高肺癌颅内转移患者总生存期,全脑放疗后对于颅内肿瘤进行局部γ-刀治疗可使颅内肿瘤明显缩小,且加量后患者总生存时间较非加量组长且存在明显统计学差异。
Objective To compare the clinical effects on brain metastases of lung cancer by whole-brain radiotherapy or whole-brain radiotherapy combined with γ-knife. Methods Totally 60 brain metastases patients were divided randomly and equally into group A and group B. The ones in group A underwent whole-brain radiotherapy, and the ones in group B went through γ-knife treatment after whole-brain radiotherapy. The patients in the two groups were compared for the tumor reduction, objective response rate（ORR） and overall survival（OS）. Results The reduction of intracranial tumor in group A was less than that in group B（P 0.05）; The ORR of group A was less than that of group B（P 0.05）; The OS of group A was significantly shorter than that of group B（P0.05）. Conclusion The whole brain radiation therapy can improve the OS of the patients with brain metastasis from lung cancer. After whole-brain radiotherapy, augmented local dosage γ- knife treatment can significantly reduce the size of intracranial tumor, and the overall survival time is significantly longer than that of non additive group.
出处
《医疗卫生装备》
CAS
2016年第7期87-89,100,共4页
Chinese Medical Equipment Journal
关键词
脑转移瘤
全脑放疗
γ-刀局部加量
临床疗效
brain metastasis
whole-brain radiotherapy
augmented local dosage with γ-knife
clinical curative effect
