摘要
目的分析精神分裂症患者不同难度认知任务下事件相关电位的特异性改变,探讨患者执行功能异常可能的发生时程。方法在Stroop范式和oddball范式下对18例精神分裂症患者(患者组)与16名健康对照者(对照组)进行事件相关电位分析,比较2组不同类型刺激条件下行为学结果,以及不同范式下脑事件相关电位改变特点。结果(1)行为学结果:Stroop范式下(一致刺激与不一致刺激)患者组【(643±129)ms与(733±123)ms】的反应时长于对照组[(525±42)ms与(592±61)ms,F=12.689,P=0.001】,患者组(93%4-11%与90%4-12%)的正确率低于对照组(99%±1%与97%±2%,F=4.353,P=0.049);视觉oddball范式下(非靶刺激与靶刺激)患者组[(419±75)ms与(512±111)msl的反应时长于对照组[(361±45)ms与(425±49)ms,F=8.174,P=0.0081,而患者组(97%±6%与90%±11%)正确率低于对照组(99%±1%与95%±4%,F=2.919,P=0.099),但差异无统计学意义。(2)脑事件相关电位结果:Stroop范式下,患者组由不一致刺激诱发的N430波幅高于一致刺激『(6.4±0.6)μV与(6.1±0.8)μV;F=3.081,P=0.047】,且在600-800ins时间窗内波形没有正向变化,缺乏正慢波,与对照组相比患者组N450和正慢波变化趋势相反;视觉oddball范式下,患者组R波幅低于对照组(F=4.657,P=0.042),而潜伏期与对照组相比差异无统计学意义。结论精神分裂症患者执行功能的异常在简单范式下并不是由刺激感知和识别缺陷导致,可能发生在任务判断和执行阶段;在复杂条件即冲突情况下,其异常从刺激感知开始持续至执行过程结束。
Objective To study negative450(N450), positive slow wave (PSW) during a specific cognitive task with conflict and visual P3 in patients with schizoprenia. Methods The electrophysiological correlations between Stroop color-word paradigm and oddball paradigm in 18 patients with schizophrenia and 16 healthy controls were compared with the reaction time(RT), accuracy rate and event related potentials (ERP) extracted from EEG data. Results Behavioral results showed in Stroop paradiam (consistent stimulus vs. inconsistent stimulus) that patients' RTs ( (643 ± 129) ms vs. (733±123) ms) were significantly prolonged (F= 12.689, P=0.001) than controls ( (525 ± 42) ms vs. (592 ±61 ) ms) and accuracy rates in patients (93% ± 11% vs. 90%± 12% )were significantly lower (F=4.353, P=0.049) than that in controls (99% ± 1% vs. 97% ± 2% ). In oddball paradiam(non-taget stimulus vs.taget stimulus) only the patients' RTs ( (419 ± 75) ms vs. (512 ± 111 ) ms)were significantly prolonged (F=8.174, P=0.008) than that in controls ((361 ± 45) ms vs. (425 ± 49) ms). ERPs showed in Stroop tasks N450 amplitude inpatients was significantly larger than that incontrols ( (6.4 ±0.6) μV vs. (6.1 ±0.8) μV, F=3.081, P=0.047 ), and the PSW in the patients was much unsteady. In visual oddball task, the P3 amplitude in patients was significantlyreduced (F=4.657,P=0.042), but no difference in RTs. Conclusions At least in simple tasks, executive function deficit of patients with schizophrenia may not caused by slowly perceiving and categorizing but by slowly selecting, preparing, or executing the appropriate response. In complicate task, the patients' reaction may be slow from preceiving stage till the end of executive process.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2016年第4期241-246,共6页
Chinese Journal of Psychiatry
基金
基金项目:国家自然科学基金(30971051)
南山区科技计划项目医疗卫生类(2014008)
深圳市科技研发资金知识创新计划基础研究项目(20130329100436293)