摘要
目的采用荟萃分析的方法评价血清乳胶凝集试验对肺隐球菌病的诊断价值,为临床早期诊断提供参考依据。方法通过计算机检索、中国知网、万方、维普和中国生物医学文献数据库,筛选出有关血清乳胶凝集试验诊断肺隐球菌病的研究,检索日期从建库开始截止至2015年8月,采用QUADAS量表对纳入的文献进行质量评价,使用荟萃Disc 1.4软件检验异质性并合并各检验效应量,Stata 12.0软件检测发表偏倚。结果最终纳入7篇文献;荟萃分析结果显示,灵敏度为0.81,特异度为0.99,阳性似然比为63.8,阴性似然比为0.22,诊断优势比为343.74,SROC曲线下面积为0.997,Q值为0.982。结论血清乳胶凝集试验诊断肺隐球菌病有较高的灵敏度及特异度,可作为早期快速诊断肺隐球菌病的重要方法。
OBJECTIVE To evaluate the value of serum latex agglutination test for diagnosing pulmonary cryptococcosis,ao as to provide an evidence for clinical early diagnosis.METHODS CNKI,Wanfang,VIP and CBM databases were searched for relevant articles about diagnosis of pulmonary cryptococcosis using serum latex agglutination test published before Aug.2015.QUADAS items were used to assess the quality of the eligible studies.Heterogeneity and meta-analysis were performed by using Disc 1.4software.Stata 12.0was used to assess potential publication bias by Deek＇s funnel plot.RESULTS Seven articles were finally included in the meta-analysis.The results of meta-analysis were as follows：sensitivity was 0.81,specificity was 0.99,positive likelihood rate was63.8,negative likelihood rate was 0.22,diagnostic odds ratio was 343.74,the AUS of SROC was 0.997 and the Q index was 0.982.CONCLUSIONThe diagnostic sensitivity and specificity of serum latex agglutination test were high for pulmonary cryptococcosis.This method could be used as an early and rapid diagnostic method for pulmonary cryptococcosis.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3364-3367,共4页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(81260663)
广西自然科学基金资助项目(2013GXNSFAA019166)
关键词
乳胶凝集试验
肺隐球菌病
诊断
荟萃分析
Latex agglutination test
Pulmonary cryptococcosis
Diagnosis
Meta-analysis
