摘要
目的：探讨青霉素、头孢菌素结合人性化护理对新生儿肺炎的治疗效果以及抗生素使用对新生儿肠道微生态的影响。方法选取无并发症的新生儿肺炎患者210例，随机数字表法分为头孢组（50例）、青霉素组（48例）、联合用药组（52例），另外选取60例健康新生儿为对照组，比较新生儿肺炎治愈时间，在使用抗生素5 d 后检测肠道菌群数量，评价抗生素对新生儿肠道微生态的影响。结果头孢组治愈率最高，达76．00％，但与青霉素组（70．83％）及联合用药组（71．15％）相比，差异无统计学意义（χ2＝2．517，P ＝0．642）。三个药物组与对照组比较，双歧杆菌数量明显降低（t ＝4．600、3．634、4．275，均 P ＜0．01），肠杆菌（t ＝4．600、3．634、4．275，均 P ＜0．01）、肠球菌（t ＝5．295、4．873、5．041，均 P ＜0．01）以及消化链球菌（t ＝3．056、2．900、3．113，均 P ＜0．01）数量显著增加，类杆菌数量差异均无统计学意义（t ＝0．112、1．096、1．943，均P ＞0．05）。结论治疗效果上，头孢类抗生素及联合用药并不优于青霉素，但临床上偏向联合用药，降低耐药的发生；抗生素会破坏新生儿肠道微生态失去平衡，危及新生儿健康。
Objective To observe the effect of two kinds of antibiotic therapeutic combined with humanistic care for neonates with infectious pneumonia and for intestinal micro ecology.Methods 210 neonates with infectious pneumonia and without complications from March 2011 to July 2013 were randomly divided into the cephalosporins group（n =50）,the penicillins group（n =48）and the combination group（n =52）,60 healthy neonates were selected as control.The cure rate,cure time in these groups were compared and the intestinal micro flora were calculated after 5 days with antibiotic treatment to evaluate the antibiotic effect to neonatal intestinal micro ecology.Results There was no significant difference between the cure rate of the cephalosporins group （76.00%）,penicillins group （70.83%）and combination group（71.15%）（χ2 =2.517,P 〉0.05）.The bifidobacteria quantity in the drug groups was significantly lower than that in the control group（t =4.600,3.634,4.275,all P 〈0.01）,while the quantity of enteric bacilli（t =4.600,3.634,4.275,all P 〈0.01）,enterococci（t =5.295,4.873,5.041,all P 〈0.01）and pep-tostreptococcus （t =3.056,2.900,3.113,all P 〈0.01 ）in the drug groups were higher than those in the control group,but the quantity of bacteroidosis had no significant difference among the three groups （t =0.112,1.096, 1.943,all P 〉0.05）.Conclusion Cephalosporin antibiotics and combination is not superior to penicillin,but in-clined to combined medication;antibiotics will destroy the neonatal intestinal micro ecological imbalance,endanger the health of newborn.
出处
《中国基层医药》
CAS
2016年第16期2461-2464,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肺炎
抗菌药
护理
肠道菌科
Pneumonia
Anti -bacterial agents
Nursing
Enterobacteriaceae
