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糖尿病肾病足细胞自噬与药物干预的研究 被引量:2

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摘要 糖尿病肾病(diabetic nephropathy,DN)是糖尿病常见的微血管并发症。蛋白尿是DN进行性加重的重要因素,越来越多的研究[1]发现足细胞损伤与DN蛋白尿的发生密切相关。细胞自噬是细胞的自我保护机制,足细胞具有较高的自噬活性,近年来研究证实[2]足细胞自噬在DN发病过程中起到重要作用。本文就近年来DN足细胞自噬与药物干预的研究进展进行一下综述。
出处 《中国中西医结合肾病杂志》 2016年第7期654-655,共2页 Chinese Journal of Integrated Traditional and Western Nephrology
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  • 1Lasaridis A N, Sarafidis P A. Diabetic nephropathy and antihypertens- ive treatment: what are the lessons from clinical trims.9 [ J]. Am J Hy- pertens, 2003, 16(8) : 689 -697.
  • 2Moliteh M E, DeFronzo R A, Franz M J, et al. Nephropathy in diabe- tes[ J]. Diabetes Care, 2004, 27 ( Suppl I ) : $79 - $83.
  • 3Stitt-Cavanagh E, MaeLeod L, Kennedy C. The podoeyte in diabetic kidney disease [ J]. SeientifieWorldJournal, 2009, 9 : 1127 - 1139.
  • 4Ziyadeh F N, Wolf G. Pathogenesis of the podoeytopathy and proteinu- ria in diabetic glomerulopathy [ J ]. Curt Diabetes Rev, 2008, 4 ( 1 ) : 39 - 45.
  • 5Meijer A J, Codogno P. Regulation and role of autophagy in mammali- an cells [ J ]. Int J Biochem Cell Biol, 2004, 36 (12) : 2445 -2462.
  • 6Hartleben B, Godel M, Meyer-Schwesinger C, et al. Autophagy influ- ences glomerular disease susceptibility and maintains podocyte homeo- stasis in aging mice[J]. J Clin Invest, 2010, 120(4) : 1084 -1096.
  • 7Tanaka Y, Kume S, Kitada M, et al. Autophagy as a therapeutic tar- get in diabetic nephropathy [ J]. Exp Diabetes Res, 2012, 2012: 628978.
  • 8Mori H, Inoki K, Masutani K, et al. The mTOR pathway is highly activa- ted in diabetic nephropathy and rapamyciu has a strong therapeutic poten- tial[J]. Bioehem Biophys Res Commun, 2009, 384(4) : 471 -475.
  • 9Yang Y, Wang J, Qin L, et al. Rapamycin prevents early steps of the development of diabetic nephropathy in rats[ J]. Am J Nephrol, 2007, 27(5) : 495 -502.
  • 10Lloberas N, Cruzado J M, Franquesa M, et al. Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney dis- ease in rats[ J]. J Am Soc Nephrol, 2006, 17 (5) : 1395 -1404.

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