摘要
目的:探讨右美托咪定与异丙酚复合麻醉对老年脑肿瘤切除术患者脑保护的效应。方法:选取2012年1月-2015年1月于我院行脑肿瘤切除术的100例老年患者为研究对象,随机分为对照组和观察组,各50例。对照组给予异丙酚复合麻醉,观察组给予右美托咪定复合麻醉,对比分析两组治疗效果。结果:在T1、T2、T3时,观察组MAP、HR明显低于对照组(P<0.05)。T1时,与T0相比,各组Sjv O_2明显升高,ajv DCO_2、OER明显降低,观察组改变幅度明显低于对照组(P<0.05)。T1、T2、T3时,与对照组相比,观察组OER、ajv DCO_2、Sjv O_2明显降低(P<0.05)。T2、T3、T4时,与T0、T1相比,观察组NSE及S100β上升水平明显低于对照组(P<0.05)。观察组麻醉恢复期改善情况明显优于对照组(P<0.05)。结论:右美托咪定复合麻醉对老年脑肿瘤切除术患者的脑保护效应优于异丙酚复合麻醉,具有进一步扩大研究的价值。
Objective：To investigate the effect of dexmedetomidine and propofol combined anesthesia for elderly from brain tumor resection.Methods：All 100 elderly patients with brain tumor resection were randomly divided into control group and observation group,50 cases in each.The control group received propofol combined anesthesia,observation group were given dexmedetomidine combined anesthesia.Results：At T1,T2,T3,the observation group MAP,HR was significantly lower than control group（ P〈0.05）.At T1,compared with T0,each group Sjv O2 significantly increased,ajv DCO2,OER significantly lower magnitude in the observation group was significantly lower than the control group（ P〈0.05）.At T1,T2,T3,compared with the control group,the observation group OER,ajv DCO2,Sjv O2 were significantly lower（ P〈0.05）.At T2,T3,T4,compared with T0,T1,NSE and S100β observation group were significantly lower than the control group（ P〈0.05）.Recovery from anesthesia in observation group was better than the control group（ P〈0.05）.Conclusion：Dexmedetomidine combined anesthesia for brain tumor resection in the elderly patients with brain protective effect was better than propofol combined anesthesia.
出处
《现代肿瘤医学》
CAS
2016年第17期2793-2795,共3页
Journal of Modern Oncology
基金
湖北省卫生厅科研重点项目(编号:JX6A04)
