摘要
目的探讨FOLFOX同步放疗对T3-T4期结直肠癌手术疗效及预后的影响。方法回顾性收集本院2008年6月至2012年5月收治的T3-T4期结直肠癌患者125例,分为单纯手术治疗组(对照组,61例)以及FOLFOX方案化疗同步放疗后手术治疗组(治疗组,64例)。观察术前FOLFOX方案化疗同步放疗对结直肠癌患者的肿瘤切除率、手术相关并发症、保肛率、3年复发率及生存率的影响。结果对照组和治疗组分别有28例和45例肿瘤完全切除,差异有统计学意义(P<0.01)。对照组和治疗组分别有9例和19例切除肿瘤后行保肛手术(P=0.04);两组患者在总生存率和复发率差异均无统计学意义,但在第1、2年的复发率和生存率差异有统计学意义。结论局部晚期结直肠患者术前行FOLFOX方案同步放疗能够提高肿瘤切除率和保肛率,降低近期复发率。
Objective To investigate the curative effect of FOLFOX combined with radiotherapy for locally advanced colorectal cancer （T3, T4） and postoperative tumor recurrence and survival rate. Methods Clinical data of 125 cases with locally advanced colorectal cancer （T3, T4） in our hospital from June 2008 to May 2012 were retrospectively analyzed. The patients were divided into control group （traditional surgery, 61 cases） and treatment group （radiotherapy＋chemotherapy FOLFOX scheme before surgery, 64 cases）. The colorectal cancer resection rate, anal anastomosis rate, postoperative complications, tumor recurrence after 3 years, survival rate, and correlation between postoperative recurrence rate were observed. Results There were 28 and 45 cases undergoing complete tumor resection in control group and treatment group respectively, with statistical difference between the two groups （P〈0.01）. Low rectal anastomosis in control group and treatment group were 9 and 19, with significant difference （P=0.04）. There was no obvious difference between the two groups in postoperative complications, total accumulative postoperative recurrence, survival rate in 3 years. Conclusion FOLFOX chemotherapy combined with radiation therapy can improve tumor resection rate, and anal preservation rate, reduce recurrence rate and increase survival rate in patients with locally advanced colorectal cancer.
出处
《中华普通外科学文献（电子版）》
2016年第4期247-250,共4页
Chinese Archives of General Surgery(Electronic Edition)
