摘要
目的探讨长骨釉质瘤的临床病理特征、诊断与鉴别诊断及其组织发生。方法对1例长骨釉质瘤进行病理形态学观察及免疫组化分析。结果长骨釉质瘤的特征性改变为兼具上皮样细胞和纤维样梭形细胞2种成分,两者以不同的比例和形态相互交织排列。免疫组化示上皮样细胞CK、CK5和CK19(+),CK7和CK8/18(-);梭形细胞vimentin(+),bcl-2和CD99均(-)。结论长骨釉质瘤为双向分化的低度恶性肿瘤,形态多样,需结合肿瘤的组织形态和免疫组化特点对其进行诊断与鉴别诊断。
Objective To study the clinicopathological features, diagnosis, differential diagnosis and histogenesis of adamantinoma of long bones. Methods One case of adamantinoma of long bones was analyzed at light microscopic level and studied by immunohistochemical staining. Results The epithelial and fibrous components belonged to the characterizations of adamantinoma of long bones, which were intermingled with each other in various proportions and differentiation patterns. CK, CK5 and CK19 were positive, while CK7, CK8/18 were negative in the epithelial ceils. Bcl-2 and CD99 were negative too. Fibrous stroma cells were vimentin positive. Conclusion Adamantinoma of long bones is a low grade malignant and biphasic tumor. The diagnosis and differential diagnosis of it should be made by combination of histopathology with immunohistochemical findings.
出处
《诊断病理学杂志》
CSCD
2016年第8期620-622,共3页
Chinese Journal of Diagnostic Pathology
关键词
长骨釉质瘤
诊断
鉴别诊断
Adamantinoma of long bones
Diagnosis
Differential diagnosis
