摘要
白细胞介素17(IL-17)是近年新发现的细胞因子,主要表达于激活的CD4^+T细胞。IL-17家族可诱导多种趋化因子以及前炎性因子分泌,参与免疫调节和炎症反应。IL-17在多种肝脏炎症性疾病中的表达明显增高,如自身免疫性肝病、非酒精性脂肪性肝病、药物性肝损伤、慢性肝炎和肝癌,并与疾病的炎症程度呈正相关。本文就IL-17与相关肝病的关系作一综述。
Interleukin-17 （IL-17） is a cytokine discovered in recent years, and is mainly expressed in activated CD4＋ T lymphocytes. IL-17 family can induce the secretion of multiple chemokines and pre-inflammatory factors, and participates in immunological regulation and inflammatory reaction. IL-17 expression is increased in various liver inflammatory diseases, such as autoimmune hepatitis, non-alcoholic fatty disease, drug-induced liver injury, chronic viral hepatitis and hepatic cancer, and is positively correlated with the degree of inflammation of the disease. This article reviewed the relationship between IL-17 and related liver diseases.
出处
《胃肠病学》
2016年第7期442-445,共4页
Chinese Journal of Gastroenterology
