摘要
目的了解甘肃省东乡县血脂异常人群流行病学特征,通过对血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）的检测、并结合相关的流行病学调查,以期为血脂异常的预防和其风险因素的控制提供参考。方法分层整群随机抽样法对甘肃省东乡县1 000例常住居民进行了包括问卷调查、体格检查以及血脂、血糖水平检查在内的综合评估。以血脂异常为因变量,以民族、性别等为自变量进行Logistic回归分析。结果东乡族血脂TC、LDL-C明显高于汉族,60岁以上老年人血脂TC、TG和LDL-C明显高于45-59岁中年人群。东乡族血脂异常率明显高于汉族,其中血脂TG、LDL-C异常率差异具有统计学意义（P〈0.05）;60岁以上老年人血脂异常率高于45-59岁中年人群,其中血脂TG、LDL-C异常率差异具有统计学意义（P〈0.05）。在不同民族人群中,东乡族和汉族60岁以上老年人血脂异常率均明显高于45-59岁中年人群。东乡族老年人血脂TG、HDL-C、LDL-C异常率明显高于中年人;汉族老年人血脂TG、HDL-C异常率明显高于中年人。在不同年龄段中,60岁以上老年人群东乡族血脂异常率明显高于汉族,以血脂TC、TG、LDL-C异常为主;45-59岁中年人群东乡族血脂异常率明显高于汉族,以血脂TG、LDL-C异常为主。对可能造成血脂异常的15个因素分析,结果显示：年龄、民族为血脂异常的危险因素。结论甘肃东乡县中老年居民血脂异常发生率处于较高水平,其中东乡族中老年人血脂异常率明显高于汉族,60岁以上老年人群明显高于45-59岁中年人群。甘肃省东乡县常住居民血脂异常与当地人群年龄、民族、吸烟、高血压和体质量指数（BMI）关系密切,其中民族和年龄因素对血脂异常的影响比较大。
Objective To investigate the abnormal incidence of serum cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C） among the mid-aged and elderly people of Dongxiang minority area in Gansu province and provide the basis for the prevention and treatment of cardiovascular disease such as hypertension and diabetes mellitus. Methods Questionnaire investigation and physical examination among 1 000 people over 45 years of Dongxiang minority area in Gansu province were carried out by stratified random sampling method. The serum levels of TC, TG, HDL-C and LDL C were detected. Results TC and LDL C of Dongxiang were significantly higher than those of Han. Meanwhile, TC, TG and LDL-C of 60 years old or older were significantly higher than 45 to 59 years old and middle-aged people. The dyslipidemia rate of Dongxiang was significantly higher than that of Han and the rate of abnormal TG and LDL-C had significant differences （ P d0.05）. And the dyslipidemia rate of old people over 60-year-old was higher than that of 45 to 59 years old and middle-aged people. At the same time, the rate of abnormal TG and LDL-C had significant difference （P （0.05）. The dyslipidemia rate of over 60-year-old in Dongxiang and Han among the different ethnic groups were significantly higher than those of 45 to 59 years old and middle-aged people. TG, HDL-C and LDL-C abnormal rate of elder people in Dongxiang were significantly higher than those of middle age and TG and HDL-C abnormal rate of elder people in Han were significantly higher than those of middle aged people. In different age groups, dyslipidemia rate of the elder people over 80 year old in Dongxiang was significantly higher than that of Han, especially TC, TG and LDL-C. And dyslipidemia rate of 45 to 59 years old and middle-aged in Dongxiang were significantly higher than those of Han, especially TG and LDL-C. Fifteen factors of dyslipidemia factors were analyzed, statistically significant factors were analyzed again. The final results showed that age and nationality were the risk factors of dyslipidemia. Conclusion Dyslipidemia rate of middle-aged and elder people in Dongxiang county of Gansu is higher, the dyslipidemia rate of elder people in Dongxiang is significantly higher than that of Han and the elder people over 60 years old are significantly higher than those of 45 to 59 years old and middle-aged people. Dyslipidemia of residents in Dongxiang county of Gansu has the relation with the age, nationality, smoking, high blood pressure and BMI, of which the ethnic and age factor are great impact factors.
出处
《临床荟萃》
CAS
2016年第8期869-874,共6页
Clinical Focus
基金
甘肃省卫计委行业项目(GSWSKY-2015-12)
国家自然科学基金资助项目(81360114)
甘肃省陇原青年创新人才扶持计划[甘组通字(2014)4号]
甘肃省科技攻关项目(1305TCYA03)
