摘要
目的探讨冠状动脉血流储备分数(fractional flow reserve,FFR)测定在冠状动脉粥样硬化性心脏病(冠心病)介入治疗中的指导作用。方法病例来源于2014年4月至2015年10月在梅州市人民医院心血管内科就诊并接受冠状动脉造影的冠心病临界病变患者90例(共170处病变),按随机数字表法分为观察组和对照组,每组45例。对照组根据冠状造影结果、遵循权威治疗指南,给予患者行经皮冠状动脉介入治疗或药物保守治疗,观察组根据FFR测定结果给予患者行经皮冠状动脉介入治疗或药物保守治疗。比较两组的基线资料、治疗情况、治疗半年内出现的心血管主要不良反应的发生情况及心绞痛的再发率。结果两组性别、年龄、其他病史及血脂指标等基线资料比较,差异无统计学意义(P>0.05)。两组的病变数目及手术时间比较,差异无统计学意义(P>0.05)。观察组住院费用及置入支架数比对照组明显更低或更少,差异有统计学意义(P<0.05)。观察组再发血运重建率、再发心肌梗死率及复发心绞痛率明显少于对照组,差异具有统计学意义(P<0.05)。结论采用FFR测定指导下行冠心病介入治疗临床效果显著,能减少心血管不良反应的发生情况及心绞痛的再发率,减少使用支架的数量,避免了支架内再血栓的发生,安全性高,还降低了住院花费,减轻患者家庭经济负担,值得在临床推广使用。
Objectives To explore the guiding effect of coronary fractional flow reserve （FFR） in interventional treatment for coronary heart disease. Methods Totally 90 patients （ 170 lesions） diagnosed with borderline lesions of coronary artery disease by coronary angiography from April 2014 to October 2015 in People＇s Hospital of Meizhou City were enrolled in this study. They were randomly divided into observation group （n=45） and control group （n=45）. Patients in control group received coronary artery interventional treatment or medical conservative treatment according to the results of coronary angiography. Patients in observation group received coronary artery interventional treatment or medical conservative treatment according to the results of coronary FFR. Baseline data, treatment condition, incidence of major cardiovascular adverse reactions and recurrence rate of angina pectoris 6 months after treatment between the two groups were compared. Results Baseline data including gender, age, disease history and blood lipids had no significant differences between the two groups（P〉0.05 ）. Numbers of lesions and duration of operation between the two groups had no significant differences （P〉O.05）. Hospitalization expenses and numbers of stents implanted in observation group were obviously lower than those in control group （P〈O.05）. Incidences of recurrent revascularization, recurrent myocardial infarction and recurrent angina pectoris in observation group were significantly lower than those in control group （P〈 0.05）. Conclusions Effect of FFR in guiding percutaneous coronary intervention is remarkable, which can reduce occurrence of cardiovascular adverse reactions and angina recurrence rate, reduce the amount of stents implanted, avoid occurrence of stent thrombosis and reduce hospitalization cost. It is worth being applied clinically.
出处
《岭南心血管病杂志》
2016年第3期283-286,共4页
South China Journal of Cardiovascular Diseases
基金
梅州市科技局课题(项目编号:2014B02)
关键词
冠状动脉疾病
血流储备分数
动脉造影
介入治疗
coronary heart disease
fractional flow reserve
angingraphy
interventional therapy
