摘要
目的探讨CTGF、VEGF在慢性阻塞性肺病吸烟患者中的相关性。方法选择2012年1月至2016年4月健康非吸烟者、健康吸烟者各60例,COPD并肺心病非吸烟者、COPD并肺心病吸烟者各60例,对比四组患者的CTGF与VEGF水平。结果健康非吸烟者的VEGF及CTGF的蛋白表达均低于健康吸烟者及COPD并肺心病非吸烟者,有统计学差异(P<0.05);健康吸烟者的VEGF及CTGF的蛋白表达均低于COPD并肺心病吸烟者,有统计学差异(P<0.05);COPD并肺心病非吸烟者VEGF及CTGF的蛋白表达均低于COPD并肺心病吸烟者,有统计学差异(P<0.05)。结论 COPD患者的VEGF及CTGF均高于正常人,吸烟是COPD病情进展的危险因素,临床上应引起重视,合理干预以控制病情。
Objective To investigate the correlation between VEGF and CTGF in smoking patients with chronic obstructive pulmonary disease. Methods 60 cases of healthy non smokers and healthy smokers during the period from January 2012 to April 2016, and 60 cases of non smokers, COPD and pulmonary heart disease were compared between groups. The levels of CTGF and VEGF were compared between the four groups. Results Non smokers of VEGF and CTGF protein expression were lower than those of healthy smokers and COPD and cor pulmonale nonsmokers, a statistically significant difference（P〈0.05）; healthy smokers, VEGF and CTGF protein expression were lower than those in COPD and cor pulmonale smokers, a statistically significant difference（P〈0.05）; non smokers of VEGF and CTGF protein expression were lower than those in COPD and cor pulmonale smokers in COPD and cor pulmonale. There was statistically significant difference（P〈0.05）. Conclusion VEGF and CTGF of COPD patients are higher than normal, smoking is the risk factors of COPD disease progression, clinical should be paid attention to, reasonable intervention to control the disease.
出处
《中国医药指南》
2016年第22期26-27,共2页
Guide of China Medicine
