摘要
目的联合抗氧化剂牛磺酸与美托洛尔降压对自发性高血压大鼠(SHR)脂代谢的影响。方法对SHR经美托洛尔(M)与牛磺酸(T)治疗2周,测定给药前后SHR血清总胆固醇(TC)、低密度脂蛋白胆固醇(L-DLC)、甘油三酯(TG),血浆ox-LDL,血清NO的含量。结果 (1)给药后M组SHR血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)以及甘油三酯(TG)的含量均升高,T组降低。(2)ox-LDL:T组可以明显降低血浆中ox-LDL的含量,由用药前(33.45±5.48)pg/dl降至(21.91±5.55)pg/dl(P<0.05),M组则由用药前(31.27±3.11)pg/dl升至(47.45±4.87)pg/dl(P<0.05),T+M组由用药前为(31.64±4.52)pg/dl增至(36.36±6.25)pg/dl(P>0.05)。(3)合用组使血清NO水平显著升高,用药前(18.64±11.00)μmol/L升至(20.96±7.89)μmol/L(P<0.05)。结论美托洛尔发挥降压作用同时可能发生脂代谢紊乱,联合抗氧化剂牛磺酸可发挥积极的调脂作用。
Objective To investigate the combination of taurine and metoprolol therapy on the lipometabolism of spontaneous hypertensive rat（SHR）. Methods SHR were treated by the taurine and metoprolol therapy for 2 weeks, and the levels of serum total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, triglyceride（TG）, plasma oxidatively modified low-density lipoprotein（ox-LDL）, serum NO were determined. Results（1） After administration, the serum total cholesterol（TC）, low density lipoprotein cholesterol（LDLC） and triglyceride（TG） in the M group were all increased, and the T group was decreased in SHR group.（2） Group ox-LDL, significantly reduce the content of plasma ox-LDL in T group, from before treatment（33.45±5.48） pg/dl fell（21.91±5.55） pg/dl（P0.05）. In group M, from before treatment（31.27±3.11） pg/dl rose（47.45±4.87） pg/dl（P0.05）. T＋M from before treatment to（31.64±4.52） pg/dl increased（36.36±6.25） pg/dl（P0.05）.（3） The serum NO level was significantly higher in the combination group, and（18.64±11.00） μmol/L before treatment（20.96±7.89） μmol/L（P0.05）. Conclusion These results suggest that the lipometabolism disturbance may be induced by metoprolol, taurine plays a positive role in lipometabolism.
出处
《中国继续医学教育》
2016年第22期210-212,共3页
China Continuing Medical Education
基金
山西省留学回国人员择优资助项目(2014A027)
山西省科技厅国际合作项目(2013081059)
