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吉西他滨在高危非肌层浸润性膀胱癌二次电切术后的应用 被引量：4

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摘要 目的观察高危非肌层浸润性膀胱癌(NMIBC)二次电切术后应用吉西他滨膀胱灌注预防术后复发的疗效。方法选择2011年8月至2013年1月该院收治的60例高危(多发、T1、G3、Tis)NMIBC患者作为研究对象,且均行经尿道膀胱肿瘤二次电切术,术后将其随机分为观察组和对照组,各30例。观察组给予吉西他滨行膀胱灌注化疗,对照组行吡柔比星膀胱灌注化疗。术后随访2年,观察两组患者肿瘤复发情况及不良反应发生情况。结果观察组总复发率[23.3%(7/30)]低于对照组[36.7%(11/30)],差异有统计学意义(P<0.05)。观察组发生不良反应1例,对照组2例,主要表现均为尿路刺激症状和血尿,但两组不良反应发生情况比较,差异无统计学意义(P>0.05),对症治疗后均缓解,两组患者均未发生严重不良反应。结论高危NMIBC二次电切术后应用吉西他滨膀胱灌注能较好地预防术后复发,且不良反应少,可成为临床预防肿瘤复发的较好选择。
作者 李利军 马志伟 龚百生 邱明星
机构地区 四川省医学科学院/四川省人民医院泌尿外科
出处 《现代医药卫生》 2016年第16期2560-2561,共2页 Journal of Modern Medicine & Health
关键词 脱氧胞苷/类似物和衍生物 膀胱肿瘤 肿瘤浸润 肿瘤复发
分类号 R737.14 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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二级参考文献14

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共引文献18

同被引文献26

引证文献4

二级引证文献9

现代医药卫生
2016年 第16期

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