摘要
目的探讨普拉克索对帕金森病患者血清胱抑素C、抗氧化指标及脑源性神经营养因子(brain derived neurotrophic factor,BDNF)的影响。方法回顾性选取郑州大学附属洛阳市中心医院治疗的帕金森病患者96例,按随机数字表法分组,对照组48例予以左旋多巴治疗,研究组48例在对照组基础上予以普拉克索治疗,采用帕金森氏病综合评分量表(unified Parkinson's disease rating scale,UPDRS)评定运动及非运动症状,采血测定血清胱抑素C、抗氧化指标及脑源性神经生长因子水平,同时对比临床疗效及不良反应。结果对照组治疗有效率68.75%低于研究组治疗有效率87.50%,差异具有统计学意义(P<0.05);与对照组比较,研究组治疗后运动症状及非运动症状均降低,治疗后血清C反应蛋白(CRP)、胱抑素C降低,BDNF升高,治疗后血浆血浆谷胱甘肽(glutathione,GSH)、过氧化氢酶(catalase,CAT)、超氧化物歧化酶(superoxide dismutase,SOD)和谷胱甘肽过氧化物酶(glutathione peroxidate,GPX)均升高,差异具有统计学意义(P<0.05)。结论采用普拉克索能降低帕金森病患者血清胱抑素C,提高BDNF水平及抗氧化能力,效果显著。
Objective To investigate the effects of pramipexole on serum cystatin C,antioxidant indexes and brain derived neurotrophic factor（ BDNF） in the treatment of patients with Parkinson＇s disease. Methods Retrospective a total of 96 patients with Parkinson＇s disease were collected and randomly divided into experimental group and control group with 48 cases in each group. Patients in the control group were treated by levodopa,patients in the experimental group were treated on the basis of the control group with pramipexole,movement and non-movement symptoms were assessed by unified Parkinson＇s disease rating scale（ UPDRS）,the serum cystatin C,antioxidant indexes and brain derived neurotrophic factor levels were measured,and the clinical efficacy and adverse reactions were compared. Results The effective rate of the control group（ 68. 75%） was lower than the experimental group（ 87. 50%）,with statistical significance（ P〈0. 05）; compared with the control group,the movement and non-movement symptoms of the experimental group reduced after treatment,after treatment the serum CRP,serum cystatin C decreased,serum BDNF increased,after treatment the glutathione（ GSH）,catalase（ CAT）,superoxide dismutase（ SOD） and glutathione peroxidate（ GPX） levels increased,with statistical significance（ P〈0. 05）. Conclusion Pramipexole in the treatment of patients with Parkinson＇s disease could reduce serum cystatin C,improve the levels of BDNF and antioxidant capacity,the effect is remarkable.
出处
《中国生化药物杂志》
CAS
2016年第6期70-72,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
普拉克索
帕金森病
胱抑素C
抗氧化指标
脑源性神经生长因子
pramipexole
Parkinson＇s disease
cystatin C
antioxidant indexes
brain derived neurotrophic factor
