摘要
目的:探究健脾解毒方促进奥沙利铂胃癌治疗的机制,为以后癌症化疗提供帮助。方法:选取我院收治的90例中期胃癌患者按随机数字表法随机分为观察组和对照组,各45例,对照组给予奥沙利铂治疗2个周期,观察组在对照组治疗的基础上给予健脾解毒方治疗2个周期。治疗前后检测各组胃癌患者肿瘤标志物癌胚抗原(CEA)、CA199含量,免疫细胞及相关免疫因子含量,血常规、肝功能及肾功能指标。结果:两组治疗前各指标比较差异无统计学意义(P>0.05);观察组经过健脾解毒方联合奥沙利铂治疗后肿瘤标志物CEA、CA199含量与对照组治疗后相比降低明显(P<0.05);治疗后观察组细胞因子与对照组相比显著提高,CD4^+和CD4^+/CD8^+与对照组治疗后相比显著升高,差异存在统计学意义(P<0.05);观察组治疗前后白细胞、红细胞及血小板水平变化不明显(P>0.05),与治疗前相比,对照组化疗后血常规各项指标明显降低(P<0.05);肝功能及肾功能检测显示观察组经过健脾解毒方联合奥沙利铂治疗后各项指标比治疗前降低明显(P<0.05),而对照组化疗后个指标比治疗前显著提高(P<0.05)。结论:健脾解毒方能够提高肿瘤患者的免疫能力,降低化疗药物的毒副作用,提化疗药物的癌症治疗效率,对癌症的康复及患者生活质量的改善具有十分重要的临床意义。
Objective： To explore the mechanism of Jian Pi Jie Du Prescription promoting oxaliplatin in the treatment of gastric cancer,to provide help for cancer chemotherapy. Methods： Ninety cases of middle gastric cancer patients in our hospital were randomly divided into the observation group and the control group according to the random number table method,45 cases in each group.Patients of the control group were treated with oxaliplatin for two cycles; based on it,patients of the observation group were treated with Jian Pi Jie Du decoction for two cycles. The carcino embryonie antigen（ CEA）,CA199 levels,immune cells and related immune factors content,blood routine,liver function and renal function index sign were compared between the two groups before and after treatment.Results： There were no significant differences in the indexes between the two groups before treatment（ P〈0. 05）; after Jianpi Jiedu decoction combined with oxaliplatin treatment,tumor markers CEA and CA199 in observation group were significantly decreased compared with the control group（ P〉0. 05）; after treatment,cytokines in observation group was significantly improved compared with the control group,CD4~＋and CD4~＋/ CD8~＋in observation group were significantly increased compared with the control group（ P〈0. 05）;before and after treatment,leucocyte and erythrocyte as well as blood platelet in observation group had no significant differences（ P〈0. 05）; blood routine indexes in control group decreased significantly after treatment（ P〈0. 05）; in comparsion with those before treatment,liver function and renal function were significantly decreased in observation group patients after Jianpi Jiedu decoction combined with oxaliplatin treatment（ P〈0. 05）,while the indexes of the control group were significantly improved after chemotherapy（ P〈0. 05）. Conclusions： Jianpi Jiedu Decoction can improve the immunity of tumor patients and reduce the toxic and side effects of chemotherapy drugs. It is of great significance to improve the efficiency of chemotherapy drugs in the treatment of cancer,and the quality of life in cancer patients.
出处
《海南医学院学报》
CAS
2016年第16期1859-1862,共4页
Journal of Hainan Medical University
基金
江苏省卫生厅科技项目(J2014118)~~
关键词
胃癌
健脾解毒方
奥沙利铂
机制
Gastric cancer
Jianpi Jiedu Prescription
Oxaliplatin
Mechanism
