摘要
目的探讨静脉丙种球蛋白与甲泼尼龙结合用于重症手足口病治疗疗效及安全性。方法选取我院2014年门诊及住院部收治的1120例重症手足口病患者进行对比试验,将其分为常规组、丙种球蛋白组、甲泼尼龙组、联合组,分别对各组患者进行相应手段治疗,并对比其治疗效果。结果采用静脉丙种球蛋白与甲泼尼龙结合用于重症手足口病治疗效果好,患者症状消退时间短,与其他组相比差异有统计学意义(P<0.05),丙种球蛋白组及甲泼尼龙组与常规组比较,治疗效果差异有统计学意义(P<0.05),但部分症状缓解时间与常规组比较差异无统计学意义(P>0.05)。结论采用静脉丙种球蛋白与甲泼尼龙结合用于重症手足口病治疗,治疗效果显著,症状消退时间及治愈时间短,未发生重症患者转为危重患者现象,且安全性较高,值得推广。
Objective To discuss curative effect and safety of intravenous immune globulin （ IVIG） and methylpred- nisolone combined severe hand, foot and mouth disease （ HFMD） treatment. Methods 1120 cases of severe hand, foot and mouth disease patients in our hospital in 2014 were studied by comparative test. Those cases were regrouped into conventional group, IVIG group, methylprednisolone group and combined treatment group. Patients in different groups received respective treatments and curative effects of them were compared. Results IVIG and methylprednisolone combined treatment has admirable cura- ctive effect to severe HFMD. It has discernably short patient symptom resolution time compared with the other groups （P 〈0. 0 5 ） . Compared with conventional group, IVIG group and methylprednisolone group have notable curative effect （P 〈0. 05） , but some of their symptom relief time are indiscriminative （ P 〉 0. 05 ） . Conclusion IVIG and methylprednisolone combined treatment has outstanding curative effect, short patient symptom resolution time and short cure time . No severe patients developed into critically ill patients. With good security, IVIG and methylprednisolone combined treatment deserve generalization.
出处
《四川医学》
CAS
2016年第8期933-936,共4页
Sichuan Medical Journal
关键词
丙种球蛋白
甲泼尼龙
重症手足口病
immunoglobulin
methylprednisolone
severe hand,foot and mouth disease
