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HPV-DNA检测、TCTT筛查方法在低年龄段及绝经后妇女宫颈病变中应用价值 被引量:3

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摘要 目的评价HPV-DNA检测和TCT检测在宫颈病变筛查中的应用价值;方法对来我院就诊的并经病理学检查确诊的151例妇女进行回顾性分析,将HPV-DNA检测、细胞学检测和阴道镜检测结果进行对比分析,三者都以病理学检测为金标准.结果HPV阳性率为72.85%,TCT检测的阳性率为77.48%,HPV-DNA检测的阳性率在CINⅡ、CINⅢ高,与低级别病变(CINⅠ/慢性宫颈炎)比较差异具有统计学意义,而TCT检测在各级别病变中的阳性率差异无统计学意义.HPV-DNA、TCT、HPV-DNA+TCT检测的灵敏度、特异度、阳性预测值、阴性预测值分别为(84.91%、55.56%、81.82%、60.97%;82.08%、33.33%、74.36%、44.12%;98.11%、17.78%、73.76%、70.00%).结论HPV-DNA检测、TCT检测、HPV-DNA与TCT联合检测三种方法中,HPV-DNA检测有较高的灵敏度和特异性,阴性预测值也较高;联合检测提高了灵敏性和阴性预测值,但其特异度低,性生活史的低年龄段妇女以及绝经后妇女也应常规进行HPV及TCT的联合筛查.
出处 《中华临床医师杂志(电子版)》 CAS 2016年第11期300-301,共2页 Chinese Journal of Clinicians(Electronic Edition)
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