摘要
目的 了解新疆南疆地区6～12岁儿童棘球蚴病患病情况，为制定相关防治策略提供科学依据。 方法 2012年8月-2013年9月采取整群分层抽样方法对新疆南疆5地（州）42个县（市）按照牧区、半农牧区、农区和城镇每层各抽取1所小学，在家长知情同意的情况下，对抽样小学的所有儿童（6～12岁）进行腹部B型超声检查和采集静脉血（5 ml），用ELISA检测棘球蚴病血清IgG抗体水平。分析该年龄段儿童的棘球蚴病的患病和血清抗体阳性情况。 结果 共调查168所小学80 429名儿童。B超检查结果显示，棘球蚴病患病者9例，患病率为0.01%；分布在克州3例、阿克苏地区2例、巴州2例、喀什地区2例。ELISA检测结果显示，血清抗体阳性者4 189例，阳性率为5.21%，其中喀什地区儿童血清抗体阳性率最高，为8.41%（2 143/25 495），阿克苏地区次之（5.69%，913/16 051），不同地区（州）之间的差异有统计学意义（χ2=977.303，P〈0.01）；6岁组血清抗体阳性率最低，为2.13%（44/2 065）；11岁组最高，为5.68%（822/14 462），各年龄组之间的差异有统计学意义（χ2=48.221，P〈0.01）；调查儿童涉及28个民族，血清抗体阳性率以维吾尔族儿童最高，为5.19%（3 899/75 115），蒙古族的次之（4.27%，68/1 592），不同民族间的差异无统计学意义（χ^2=4.072，P〉0.05）。生活方式以定居、游牧、冬季定居夏季游牧为主，定居儿童患病7例，冬季定居夏季游牧儿童患病2例；血清抗体阳性率分别为5.45%（4 184/77 512）、2.97%（3/101）、0.07%（2/2 816），三者差异有统计学意义（χ^2=148.609，P〈0.01）。 结论 新疆南疆地区6～12岁儿童棘球蚴病患病率较低，血清抗体阳性率在喀什地区、维吾尔族、定居儿童中较高。
Objective To understand the hydatidosis prevalence in 6- to 12-year-old children in southern Xinjiang Uygur Autonomous Region and provide scientific basis for formulation of control measures. Methods One primary school was selected from each of the pastoral area, pastoral-agricultural area, agricultural area, and township area in 42 counties （cities） of southern Xinjiang, using the stratified sampling method. With the consent of their parents, B ultrasonic abdominal scan and venous blood collection were performed on all the children （6-12 years） in the selected schools. Serum level of echinococcus antibody IgG was determined by ELISA. Hydatidosis prevalence and the serum level of IgG in these children were analyzed. Results A total of 80 429 children were examined from 168 primary schools. B ultrasonic scan revealed hydatidosis in 9 children （0.01%）, comprising 3 cases in Kezhou, 2 in Aksu, 2 in Bazhou, and 2 in Kashi. ELISA results showed that 4 189 children were positive for serum IgG, with a positive rate of 5.21%. The positive rate was highest in Kashi （8.41%, 2 143/25 495）, followed by Aksu （5.69%, 913/16 051）, with significant difference between different areas （χ^2=977.303, P〈0.01）. The positive rate was lowest in 6-year children （2.13%, 44/2 065） and highest in 11-year children （5.68%, 822/14 462） （χ^2=48.221, P〈0.01）. In addition, the positive rate was highest in Uighur children（5.19%, 3 899/75 115）, followed by Mongolian children （4.27%, 68/1 592）, with no significant difference between ethnic groups （χ^2=4.072, P〉0.05）. Among the children of residents, children with a nomadic lifestyle, and children settled in winter and living in a nomadic lifestyle in summer, hydatidosis occurred in 7 residents and 2 children who settled in winter and living in a nomadic lifestyle in summer; and the positive rate of serum antibody was 5.45% （184/77 512）, 2.97% （3/101）, 0.07% （2/2 816）, respectively（χ^2=148.609, P〈0.01）. Conclusion There is a low hydatidosis prevalence in 6- to 12-year-old children in southern Xinjiang, but the positive rate of serum echinococcus IgG in kashgar region, Uighur ethnicity, and children of the resident group are relatively high.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2016年第4期370-372,376,共4页
Chinese Journal of Parasitology and Parasitic Diseases
