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宫颈癌筛查中HPV检测初筛的分流检测 被引量：12

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摘要 宫颈癌是常见的恶性肿瘤,只有进行有效的筛查才能做到早发现、早诊治,降低宫颈癌的发病率与死亡率。目前国内外宫颈癌筛查方案多样,但均有不同的局限性。随着高危型人乳头瘤病毒(HR-HPV)与宫颈癌及癌前病变关系的深入研究,HPV检测也成为宫颈癌筛查中重要的部分。HPV检测初筛对于宫颈癌及癌前病变的检出具有较高的敏感性,但特异性较低。国内外研究者不断探索新式检测方法对HPV阳性者进行分流检测,以提高宫颈癌筛查的效力。目前国内外有关HPV阳性者分流检测的方法包括细胞学检测分流、HPV分型检测分流、HPV mRNA检测分流、分子标志物分流等。各种检测方法均有利弊,一些检测相关标志物的研究仍处于起步阶段,需大宗设计严谨的临床试验进行验证。
作者 韩钦 郭红燕
机构地区 北京大学第三医院
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2016年第8期577-580,共4页 Journal of Practical Obstetrics and Gynecology
关键词 宫颈癌筛查 HPV检测 分流检测
分类号 R737.33 [医药卫生—肿瘤]
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参考文献20

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实用妇产科杂志
2016年 第8期

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