摘要
黄芩作为我国的传统中药材之一,其活性成分主要为黄酮类化合物,国内外研究表明,其多种活性成分均具有良好的抗炎作用。目前随着对炎症反应的不断深入,研究者发现炎症反应的发生与多种细胞通路的激活有关,因此通过阻断炎症细胞通路,减少通路中关键蛋白的表达激活,对与缓解和治疗炎症反应有着重要的意义。研究显示黄芩中所含有的黄芩苷、黄芩素、汉黄芩苷、汉黄芩素、等在体内外对炎症反应的抑制作用与对多条主要的炎症通路的调节和阻断作用有着密切的联系,这也成为目前对黄芩抗炎研究的热点之一。本文通过相关文献,以黄芩有效成分在炎症通路中的作用为出发点,重点介绍了黄芩有效成分在炎症通路中作用的靶点蛋白,为黄芩抗炎作用的进一步研究研究提供参考。
Scutellaria baicalensis is one of the traditional Chinese medicine and its active ingredient flavonoids mainly,research shows that their active ingredients has good anti-inflammatory effects. At present,with the deepening of the inflammatory response,the researchers found that activation of the inflammatory response occurs with multiple cellular pathways related,so by blocking the pathway of inflammation,reduce the expression of key proteins in pathways activated,mitigation and treatment of inflammatory reaction is of great significance.Study show that baicalin, baicalein,Wogonoside and wogonin in vitro and in vivo inhibition of inflammation areclosely linked with regulation of a number of major inflammation pathway. Through literature,role of effective components of radix scutellariae in inflammatory pathway as a starting point,focuses on the effective components of radix scutellariae＇s role in the inflammatory pathway target proteins,provide references for further study of the antiinflammatory effects of scutellaria baicalensis.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第17期193-197,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81274111)
关键词
黄芩
炎症通路
有效成分
作用靶点
Scutellaria Radix
inflammatory pathways
active ingredients
action target
