摘要
目的分析早期宫颈癌患者采用多烯紫杉醇化疗后行宫颈癌根治术与盆腔淋巴结清扫术的疗效。方法选取2008年7月至2015年7月青岛市胶州中心医院收治的早期宫颈癌患者72例,依据抽签法分成观察组和对照组,各36例。观察组采用多烯紫杉醇化疗后行腹腔镜下宫颈癌根治术与盆腔淋巴结清扫术,对照组行单纯腹腔镜下宫颈癌根治术与盆腔淋巴结清扫术。观察比较两组患者的手术情况,术后的病理结果,癌症治疗功能评价量表(FACT-G)评分,疗效及复发情况。结果观察组的手术时间显著短于对照组[(231±8)min比(258±9)min],术中出血量显著少于对照组[(285±9)m L比(312±9)m L],排气时间显著短于对照组[(1.02±0.15)d比(1.13±0.18)d],住院时间显著短于对照组[(5.32±0.57)d比(5.84±0.62)d],差异有统计学意义(P<0.01);观察组病灶的总侵犯率显著低于对照组[2.78%(4/144)比16.67%(24/144),P<0.01];治疗后1个月观察组FACT-G评分高于对照组[(78±5)分比(70±5)分],治疗后3个月观察组FACT-G评分高于对照组[(86±5)分比(78±5)分](P<0.01);治疗后1个月观察组总有效率显著高于对照组[88.89%(32/36)比69.44%(25/36)]。两组复发率比较差异无统计学意义(P>0.05)。结论早期宫颈癌患者行宫颈癌根治术与盆腔淋巴结清扫术前联合运用多烯紫杉醇化疗的临床疗效确切,能够有效提高患者的生存质量,值得推广运用。
Objective To observe the efficacy of docetaxel chemotherapy plus early radical hysterectomy and pelvic lymphadenectomy for patients with early cervical carcinoma. Methods Total of 72 cases of early cervical cancer admitted to Qingdao Jiaozhou Central Hospital from Jul. 2008 to Jul. 2015 were included in the study,and divided into an observation group and a control group according to the drawing method,36 cases each. The observation group received docetaxel chemotherapy then underwent laparoscopic radical hysterectomy and pelvic lymph node dissection;the control group received only laparoscopic radical hysterectomy and pelvic lymphadenectomy. The surgery condition, the postoperative pathological results, and functional assessment for cancer therapy-general （FACT-G） score, efficacy and recurrence of the two groups were observed and compared. Results The operative time of the observation group was significantly shorter than the control group [ （231±8） min vs （258±9） mini ,the intraoperative blood loss was significantly less than the control group[ （285±9） mL vs （312±9） mL],exhaust time was significantly shorter than the control group [ （1.02 ± 0.15 ） d vs （1.13 ± 0. 18 ） d ] ,length of hospital stay was significantly shorter than the control group [ （5.32 ±0. 57 ） d vs （5.84 ±0. 62） d ], the differences were statistically significant （ P 〈 0.01 ） ;the total involvement of the lesions of the observation group was significantly lower than the control greup[2.78% （4/144） vs 16.67% （24/144）, P 〈 0.05 ] ; FACT-G score of the observation group one month after treatment was higher than the control group [ （78±5 ） scores vs （70±5 ） scores ] ,3 months after treatmentwas higher than the control group [ （ 86 ± 5 ） scores vs （ 78 ± 5 ） scores ] （ P 〈 0.01 ） ; the total effective rate of the observation group after one month of treatment was significantly higher than the control group[88.89% （32/36） vs 69.44% （25/36）]. There was no significant difference in recurrence rate between two groups （ P 〉 0. 05 ）. Conclusion The clinical efficacy of radical hysterectomy and pelvic lymphadenectomy joint docetaxel chemotherapy in early stage cervical carcinoma patients is precise,with high safety, which can effectively improve the quality of life of the patients, thus is worthy of promotion and application.
出处
《医学综述》
2016年第17期3458-3461,共4页
Medical Recapitulate
