摘要
目的探讨原发性肺癌患者血清中癌抗原125(CA125)、骨胶素(CY211)、癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCC)及神经元特异性烯醇化酶(NSE)的变化及其意义。方法选取2014年10月至2015年12月间临汾市人民医院就诊的50例肺癌者(A组)、50例肺良性疾病患者(B组),另选同期体检的健康人50名作为对照组,采用化学发光法检测3组肿瘤标志物的表达水平。结果 A、B两组各项肿瘤标志物水平明显高于对照组,差异有统计学意义(P<0.05)。A组患者CEA和CY211水平明显高于B组,差异有统计学意义(P<0.05)。与临床手术组织病理检查结果比较,小细胞肺癌患者NSE阳性率较其他类型肺癌高,而腺癌患者中CA125阳性率最高,鳞癌患者中CY211阳性率表达最高。结论检测肿瘤标志物,尤其是血清CEA和CY211可有利于肺癌的诊断及肺癌患者临床病理分型,可为临床治疗提供指导价值。
Objective To investigate the tumor markers（ cancer antigen 125,CY211,carcinoembryonic antigen,squamous cell carcinoma antigen（ SCC） and neuron-specific enolase） changes and significance in serum of patients with primary lung cancer. Methods Our hospital diagnosed with lung cancer were 50 cases（ Group A）,50 cases of patients with benign lung diseases（ group B） and 50 cases of healthy people as the object of this study,and detected three groups of tumor marker expression levels using chemiluminescence. Results A,B groups of the tumor marker levels were significantly higher than healthy group,the difference was significant,statistically significant,P〈0. 05. Group A patients carcinoembryonic antigen（ CEA） and CY211 levels were significantly higher than group B（ P〈0. 05）. Comparison of surgical pathology and clinical findings,nerve-small cell lung cancer patients with specific enolase（ Neuron Specific Enolase,NSE） positive rate than other types of lung cancer is high,while the highest cancer patients in cancer antigen 125（ CA125） positive rate,the positive rate of patients with squamous cell carcinoma CY211 highest expression. Conclusions Detection of tumor markers,especially serum CEA,CY211 can contribute to lung cancer,simultaneous detection of different tumor markers is also beneficial to patients with lung cancer clinical pathological type,which can provide guidance value for clinical treatment.
出处
《中国肿瘤临床与康复》
2016年第8期918-920,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
