摘要
目的评价奥沙利铂＋亚叶酸钙＋氟尿嘧啶（FOLFOX方案）联合中医药治疗Ⅱ～Ⅲ期大肠癌术后患者生存期的影响。方法选取2009年5月至2010年5月间湖南省中医药研究院附属医院（60例）、湖南省肿瘤医院（35例）、湖南省直医院（38例）、邵阳市中医院（33例）和衡阳市中医院（27例）收治的Ⅱ～Ⅲ期大肠癌术后患者193例,采用随机同期对照法分为观察组（99例）和对照组（94例）,两组均接受6个周期FOLFOX方案辅助化疗。观察组采用FOLFOX方案联合中医药治疗,对照组仅采用FOLFOX方案治疗,观察并随访记录两组患者的无病生存时间（DFS）,并统计1、2、3、4、5年生存率。结果观察组患者DFS为36.6个月,对照组为28.2个月（P〈0.05）。观察组患者1、2、3、4、5年生存率分别为99.0%、84.8%、68.7%、66.7%和65.7%,对照组分别为97.9%、74.5%、57.4%、43.6%和42.6%（P〈0.01）;结论大肠癌患者术后采用FOLFOX方案联合中医药综合治疗,可以延长生存时间,提高生存率。
Objective To evaluatethe treatment of traditional Chinese medicine on survival of Ⅱ-Ⅲ period of postoperative patientswith colorectal cancer. Methods The 193 cases of Ⅱ-Ⅲ period of postoperative patientscame from five top three hospitals of hunan province,adopted the concurrent control study,randomly divided into treatment group（ 99 examples） and control group（ 94 examples）. Two groups had chemotherapy for 6 cycles of domestic commonly used FOLFOX scheme,the treatment group receiving treatment combined with traditional Chinese medicine according to TCM treatment at the same Time,the control group no longer accepted the systematically traditional Chinese medicine treatment. The patients＇ disease-free survival（ DFS）,and1,2,3,4,and 5 years survival ratewere observed in two groups. Results The treatment groupmedian DFS was 36. 6 months,compared with 28. 2 months（ P〈0. 05）. 1,2,3,4,and 5years survival rate in treatment group,respectively,99. 0%,84. 8%,68. 7%,66. 7%,65. 7%,and the control group,respectively,97. 9%,74. 5%,57. 4%,43. 6%,42. 6%（ P〈0. 01）; Conclusion Postoperative patients with colorectal cancer systematically combined treatment of traditional Chinese medicine,can prolong patient disease-free survival,and improve survival rate.
出处
《中国肿瘤临床与康复》
2016年第8期953-955,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
湖南省中医药科研计划(2009036)
关键词
结直肠肿瘤
无病生存
中医治疗学
药物疗法
Colorectal neoplasms
Disease-free survival
Trerapeutics
Drug therapy
