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乳酸菌作为DNA疫苗载体的研究进展 被引量：8

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摘要 乳酸菌（lactic acid bacteria,LAB）属于革兰阳性、兼性厌氧菌,其基因组中GC含量较低,是一类可以利用碳水化合物发酵产生乳酸的一类菌的总称,包括肠球菌、乳杆菌、乳球菌、明串珠菌、片球菌、链球菌和双歧杆菌等众多种属,被广泛地应用于食品发酵、医药生产、保健药物及饲料添加剂等工业,美国食品和药品监督管理局（FDA）将乳酸菌认定为安全的食品级微生物[1]。
作者 刘晶 杨桂连 王春凤 姜延龙
机构地区 吉林农业大学动物科学技术学院吉林省动物微生态制剂工程研究中心
出处 《中国兽医杂志》 CAS 北大核心 2016年第7期67-69,共3页 Chinese Journal of Veterinary Medicine
基金 国家863计划项目(2013AA102806 2011AA10A215) 国家自然科学基金项目(31272552 31272541) 吉林省科技发展计划项目(20111816) 吉林省世行贷款农产品质量安全项目(2011-Y07)
关键词 DNA疫苗载体 乳酸菌 食品发酵 兼性厌氧菌 碳水化合物 饲料添加剂 GC含量 明串珠菌
分类号 Q78 [生物学—分子生物学]
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参考文献13

  • 1任晟诚,艾春青,张秋香,张灏,陈卫.乳酸菌作为粘膜重组疫苗呈递载体的研究进展[J].食品安全质量检测学报,2014,5(4):983-989. 被引量：5
  • 2Agnieszka Wyszyńska,Patrycja Kobierecka,Jacek Bardowski,et al.Lactic acid bacteria-20 years exploring their potential as live vectors for mucosal vaccination[J].Appl Microbiol Biotechnol,2015,99:2967-2977.
  • 3Sidgi Syed Anwer Abdo Hasson,Juma Khalifa Zayid Al-Busaidi,Talal Abdulmalek Sallam.The past, current and future trends in DNA vaccine immunisations[J].Asian Pacific Journal of Tropical Biomedicine,2015,5(5):344-353. 被引量：8
  • 4Sheets R L,Stein J,Manetz T S,et al.Biodistribution of DNAPlasmid Vaccines against HIV-1,Ebola,Severe Acute Respirato?ry Syndrome,or West Nile Virus Is Similar,without Integration,Despite Differing Plasmid Backbones or Gene Inserts[J].Toxico?logical Sciences,2006,91:610-619.
  • 5Vanessa Bastos Pereira,Tessália Diniz Luerce Saraiva,Bianca Mendes Souza.Development of a new DNA vaccine based on my?cobacterial ESAT-6 antigen delivered by recombinant invasive Lactococcus lactis Fn BPA+[J].Appl Microbiol Biotechnol,2015,99:1817-1826.
  • 6Guimar?es V,Innocentin S,Chatel J M,et al.A new plasmid vec?tor for DNA delivery using lactococci[J].Genet Vaccines Ther,2009,7:1-24.
  • 7Wells J M,Mercenier A.Mucosal delivery of therapeutic and pro?phylactic molecules using lactic acid bacteria[J].Nat Rev Microbi?ol,2008,6:349-362.
  • 8Chatel J M,Pothelune L,Ah-Leung S,et al.In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells[J].Gene Ther,2008,15:1184-1190.
  • 9Pontes D,Innocentin S,del Carmen S,et al.Production of Fibro?nectin Binding Protein A at the Surface of Lactococcus lactis In?creases Plasmid Transfer In Vitro and In Vivo[J].PLo S ONE,2012,7(9):e44892.
  • 10Pontes D,Azevedo M,Innocentin S,et al.Immune response elicited by DNA vaccination using Lactococcus lactis is modified by the production of surface exposed pathogenic protein[J].PLo S One,2014,9:e84509.

二级参考文献32

  • 1Natalie A. Molodecky,Ing Shian Soon,Doreen M. Rabi,William A. Ghali,Mollie Ferris,Greg Chernoff,Eric I. Benchimol,Remo Panaccione,Subrata Ghosh,Herman W. Barkema,Gilaad G. Kaplan.Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review[J].Gastroenterology.2012(1)
  • 2Belkis Marelli,Ana Rosa Perez,Claudia Banchio,Diego de Mendoza,Christian Magni.Oral immunization with live Lactococcus lactis expressing rotavirus VP8* subunit induces specific immune response in mice[J].Journal of Virological Methods.2011(1)
  • 3Hou Jing,Lu Yong,Liu Haiyan,Ma Yanjun,Xing Yun,Zhang Yu,Li Taiming,Cao Rongyue,Jin Liang,Wu Jie,Zong Li,Liu Jingjing.Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient mice[J].Vaccine.2011(24)
  • 4Mohammed Bahey-El-Din,Pat G. Casey,Brendan T. Griffin,Cormac G.M. Gahan.Lactococcus lactis -expressing listeriolysin O (LLO) provides protection and specific CD8 + T cells against Listeria monocytogenes in the murine infection model[J].Vaccine.2008(41)
  • 5Ke Wang,Lihua Huang,Jian Kong,Xiaowei Zhang.Expression of the capsid protein of porcine circovirus type 2 in Lactococcus lactis for oral vaccination[J].Journal of Virological Methods.2008(1)
  • 6Catherine Daniel,Florent Sebbane,Sabine Poiret,Denise Goudercourt,Joelle Dewulf,Chantal Mullet,Michel Simonet,Bruno Pot.Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV[J].Vaccine.2008(8)
  • 7Benoit Foligne,Rodrigue Dessein,Michael Marceau,Sabine Poiret,Mathias Chamaillard,Bruno Pot,Michel Simonet,Catherine Daniel.Prevention and Treatment of Colitis With Lactococcus lactis Secreting the Immunomodulatory Yersinia LcrV Protein[J].Gastroenterology.2007(3)
  • 8Henry R. Costantino,Lisbeth Illum,Gordon Brandt,Paul H. Johnson,Steven C. Quay.Intranasal delivery: Physicochemical and therapeutic aspects[J].International Journal of Pharmaceutics.2007(1)
  • 9Isabel Delany,Rino Rappuoli,Ennio De Gregorio.Vaccines for the 21st century[J]. EMBO Mol Med . 2014 (6)
  • 10Alida Ault,Alyse M. Zajac,Wing-Pui Kong,J. Patrick Gorres,Michael Royals,Chih-Jen Wei,Saran Bao,Zhi-yong Yang,Stephanie E. Reedy,Tracy L. Sturgill,Allen E. Page,Jennifer Donofrio-Newman,Amanda A. Adams,Udeni B.R. Balasuriya,David W. Horohov,Thomas M. Chambers,Gary J. Nabel,Srinivas S. Rao.Immunogenicity and clinical protection against equine influenza by DNA vaccination of ponies[J]. Vaccine . 2012 (26)

共引文献10

同被引文献40

引证文献8

二级引证文献15

中国兽医杂志
2016年 第7期

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