摘要
目的探讨多囊卵巢综合征（polycystic ovary syndrome,PCOS）不孕患者性激素与外周血NK细胞活性的相关性。方法将2013年3月至2014年12月于我院诊疗的105例PCOS不孕患者作为观察对象,选择75例同期就诊于我院的正常非妊娠妇女作为对照组。于月经周期第2~4天抽血行性激素检查;使用流式细胞术检测NK细胞百分比。结果 PCOS不孕患者外周血淋巴细胞中NK细胞比例显著高于对照组（分别为14.05%±6.06%和6.53%±3.49%,P〈0.05）;而NK细胞各亚群比例无显著差异（P〉0.05）;NK与E2和T的相关性有统计学意义（r=0.384和0.333;P=0.007和0.021）。结论 PCOS患者外周血NK细胞比例异常增高与内分泌失调状态有关,而NK细胞活性异常可能促进PCOS病程的发生。
This study was performed to explore the correlation between sex hormones and peripheral（PB） NKcell activity of polycystic ovary syndrome（PCOS）. Total of 105 cases of dysgenesis accepting treatments in ourhospital during March 2013 to December 2014 were recruited as the observation cases and 75 cases of normalpregnant women were selected as control group. Then hormones and PB NK cell were measured with flow cytometryin the menstrual cycle line 2-4 days. Data showed that NK cells proportion of PCOS patients was significantly higherthan that of control group（14.05%±6.06% and 6.06%±3.49%, P〈0.05）. But the rate of NK cells in each subgroupshowed no significant difference（P〉0.05）. Furthermore, correlation analysis demonstrated that NK was positivelyrelated with E2 and T（r=0.384, 0.333; P=0.007, 0.021）. In conclusion, immunologic derangement is existed in mostPCOS patients, which probably is one of the causes of high androgen state.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2016年第9期800-803,共4页
Immunological Journal
