摘要
转录因子激活蛋白-2α(transcription factor AP-2 alpha,TFAP2α)是一种能与DNA特异性结合的转录因子,它参与调节正常细胞增殖分化及胚胎发育,并通过调控信号转导来开启、关闭、增强或减弱多种靶基因的表达,对肿瘤细胞的增殖、分化、侵袭及转移发挥重要调控作用。近年来国内外对TFAP2α基因在肿瘤中的作用进行了大量研究,TFAP2α在多种肿瘤组织中存在异常表达,且表达程度与肿瘤类型、临床分期、病理分化程度等有着密切的关系,它在不同肿瘤中发挥促癌或抑癌的作用。本文重点介绍TFAP2α基因的结构和功能及其在肿瘤发生发展中的作用。
TFAP2α is a sequence-specific DNA binding transcription factor which is required for normal growth and morphogenesis. TFAP2α can increase or decrease the expression of target genes by regulating their signal transduction, and it also plays an essential regulatory role in tumor cell proliferation, differentiation, invasion and metastasis. Recent studies find that TFAP2α is differently expressed in various tumor tissues, and its expression is closely related with tumor types, clinical stage and pathological differentiation. TFAP2α is respectively involved as tumor promoter or suppressor in distinctive carcinoma. In this article, we review the function of TFAP2α in cell proliferation, differentiation and morphogenesis, and the role in tumor genesis, its structure and mechanism of activation and degradation is briefly involved.
出处
《解放军医学院学报》
CAS
2016年第8期893-896,共4页
Academic Journal of Chinese PLA Medical School
基金
国家高技术研究发展计划(863计划)(2014AA020607)~~
