摘要
目的观察多磺酸粘多糖乳膏(MPS)联合清血毒胶囊和窄谱紫外线(NB-UVB)照射治疗反相银屑病的临床疗效及安全性。方法 67例反相银屑病患者随机分为两组,治疗组34例,对照组33例。两组均给予NB-UVB照射,隔日1次,口服清血毒胶囊,3次/d,每次4粒。治疗组光疗后外用MPS,2次/d;对照组光疗后外用他卡西醇乳膏,2次/d。用药前,用药第4和第8周进行皮损评价。结果治疗4周后,治疗组和对照组总有效率分别为32.35%和24.24%,差异无统计学意义(P>0.05);第8周后治疗组和对照组总有效率分别为79.41%和54.55%,差异有统计学意义(P<0.05)。治疗期间治疗组不良反应发生率为5.88%,明显低于对照组的27.27%,差异有统计学意义(P<0.05)。结论 MPS联合清血毒胶囊内服和NB-UVB治疗反相银屑病疗效较他卡西醇好,且不良反应少,稳定性和安全性较好,可作为反相银屑病治疗的长期外用制剂。
Objective To observe the clinical efficacy of mucopolysaccharide polysulfate cream （MPS） combined with Qingxuedu capsules and narrow-band ultraviolet B （NB-UVB） on inverse psoriasis. Methods All of the 67 patients were given Qingxuedu capsules orally （4 capsules a time, three times daily） and NB- UVB every other day. They were randomly divided into 2 groups. For the 34 cases in the treatment group MPS was given twice daily, while the 33 cases in the control group were treated with Tacalcitol ointment twice daily. The clinical effects were observed before treatment, 4 and 8 weeks after treatment. Results The total effective rate was not significantly different between the treatment group and the control group after treatment for 4 weeks （32.35% vs 24.24%, P〉 0.05）. After 8-week treatment, the total effective rate of the treatment group and the control group was 79.41% and 54.55% respectively with significant difference （P〈 0.05）. The incidence of adverse reactions was 5.88% in the treatment group which was obviously lower than that of the control group （27.27%, P 〈 0.05）. Conclusions MPS has better effect, stability and security than Taealcitol in combination with Qingxuedu capsules and NB-UVB for the treatment of inverse psoriasis. It can be used as a long-term external preparation in treatment of inverse psoriasis.
出处
《中国现代医学杂志》
CAS
北大核心
2016年第17期86-89,共4页
China Journal of Modern Medicine
