摘要
目的探讨血维生素B12、血同型半胱氨酸（Hcy）联合检测在脊髓亚急性联合变性（SCD）中的诊断价值。方法 选取2010年1月~2015年12月我院神经内科住院的30例SCD患者作为SCD组,另选同期健康体检者30例作为对照组。检测两组血清Hcy及维生素B12水平,并作对比分析。结果 SCD组患者血浆维生素B12显著低于对照组,血Hcy水平显著高于对照组,差异有统计学意义（P〈0.05）。维生素B12和血Hcy单独检测SCD的灵敏度分别为68.6%、72.4%,特异度分别为45.3%、41.2%,两者联合检测SCD的灵敏度为93.8%、特异度为64.3%。结论 血浆维生素B12、血Hcy在SCD诊断中具有重要的临床意义,联合检测血浆中维生素B12、血Hcy的水平有利于提高SCD的诊断率。
Objective To evaluate the value of combined detection of Vitamin B12 and Homocysteine （Hcy） in subacute combined degeneration of spinal cord （SCD）.Methods 30 patients with SCD from January 2010 to December 2015 in neurology department of our hospital were selected into SCD group,and 30 healthy persons during the same period were randomly selected into control group from medical examination center of our hospital.Serum Hcy and Vitamin B~ levels of two groups were tested and compared.Results The concentration of Vitamin BI~ in SCD group was lower than that in control group （P〈O.05）.The concentration of Hcy in SCD group was higher than that in control group （P〈0.05）.The sen- sitivity rates of Vitamin B12 and Hcy in SCD was 68.6%,72.4% respectively,the specific rates was 45.3%,41.2% respectively.In combined assay of Vitamin B12 and Hcy,the sensitivity rate was 93.8%,the specificity rate was 64.3%.Comparing with the single assay,combined detection had much higher diagnostic sensitivity.Conclusion The detection of Vita- min BI2 and Hey respectively is significant in diagnosis of SCD.Combined detection of Vitamin B12 and Hcy can improve the diagn-ostic rate of.early SCD.
出处
《中国当代医药》
2016年第24期31-33,共3页
China Modern Medicine
