摘要
目的研究血清胱抑素C（Cys C）、基质金属蛋白酶-9（MMP-9）及同型半胱氨酸（Hcy）与脑梗死的关系。方法选择我院2014年1月至2015年6月入院的80例脑梗死患者作为脑梗死组,选择同期在我院接受体检的30例健康人群作为对照组。比较两组患者的血清Cys C、MMP-9和Hcy水平以及比较脑梗死患者不同病灶大小、预后的血清Cys C、MMP-9、Hcy水平。结果脑梗死组患者的血清Cys C、MMP-9、Hcy水平明显高于对照组（P〈0.05）;恢复期脑梗死组患者的血清Cys C、MMP-9水平低于急性期（P〈0.05）;脑梗死患者恢复期和急性期的Hcy水平相近（P〉0.05）。脑梗死组患者的血清Cys C、MMP-9水平随梗死灶的增大而升高（P〈0.05）;Hcy水平相近（P〉0.05）。预后良好组患者的Cys C、MMP-9水平明显低于预后不良组（P〈0.05）;两组患者的Hcy水平相近（P〉0.05）。多元Logistic回归分析显示血清Cys C（OR=2.724,95%CI=1.318~5.630）、MMP-9（OR=1.936,95%CI=1.362~2.752）和Hcy（OR=4.915,95%CI=1.372~17.607）水平均是脑梗死的危险因素。结论 Cys C、MMP-9和Hcy水平的增高与脑梗死的发生密切相关,Cys C和MMP-9水平还能预测脑梗死患者的预后,具有重要的临床价值。
Objective To investigate the relationship of cerebral infarction with serum cystatin C（ Cys C）,matrix metalloproteinase-9（ MMP-9）,and homocysteine（ Hcy）. Methods A total of 80 patients with cerebral infarction who were admitted to our hospital from January 2014 to June 2015 were selected as cerebral infarction group,and 30 healthy people who underwent physical examination in the same period were selected as control group. The levels of serum Cys C,MMP-9,and Hcy,as well as the size of lesion,and prognostic serum Cys C,MMP-9,and Hcy levels were all compared between the two groups. Results The cerebral infarction group had significantly higher levels of serum Cys C,MMP-9,and Hcy than the control group（ P〈0. 05）; convalescent patients with cerebral infarction had significantly lower serum Cys C and MMP-9 levels than patients in acute stage（ P〈0. 05）; convalescent and acute patients with cerebral infarction had similar Hcy levels（ P〈0. 05）. The levels of serum Cys C and MMP-9 in cerebral infarction group were positively correlated with the size of lesion（ P〈0. 05）,but the Hcy level showed no significant difference（ P〈0. 05）. Patients with good prognosis had significantly lower Cys C and MMP-9 levels than patients with poor prognosis（ P〈0. 05）,but the Hcy levels showed no significant difference（ P〈0. 05）. Multivariate logistic regression analysis showed that serum Cys C（ OR = 2. 724,95%CI： 1. 318- 5. 630）,MMP-9（ OR = 1. 936,95% CI： 1. 362- 2. 752）,and Hcy（ OR = 4. 915,95% CI： 1. 372- 17. 607） were all risk factors for cerebral infarction. Conclusions The increased levels of Cys C,MMP-9,and Hcy are closely associated with the occurrence of cerebral infarction. Cys C and MMP-9 can also make the prognosis of patients with cerebral infarction,so they are of great significance in clinical practice.
出处
《国际神经病学神经外科学杂志》
北大核心
2016年第3期233-236,共4页
Journal of International Neurology and Neurosurgery
