摘要
目的探讨介入性肝动脉栓塞/化疗栓塞治疗老年原发性肝癌合并破裂出血患者近期疗效。方法回顾性分析16例老年原发性肝癌合并破裂出血患者介入治疗资料,评价介入治疗的安全性及近期疗效。结果 15例患者治疗后出血停止,止血成功率93.8%,1例因持续出血及肝功能严重损害于1周内死亡,未发生介入相关严重并发症。转氨酶治疗后2~3天升高（P〈0.01）,7~10天恢复至术前水平（P〉0.05）,总胆红素变化不明显（P〉0.05）。12例接受后续介入治疗,随访期内肝动脉化疗栓塞1-4（平均2.5）次。3个月时14例存活,患者肿瘤客观有效率85.7%。3、6、12个月生存率为87.5%、75%、56.3%。结论介入治疗老年原发性肝癌合并破裂出血安全性较高,可以有效止血、短期内延缓肿瘤进展并改善近期预后。
Objective To explore the short-term curative effect of interventional transarterial embolization/chemoembolization（TAE/TACE）treatment on senile patients with rupture and bleeding of primary liver carcinoma（PLC）.Methods A total of 16 senile PLC patients with rupture and bleeding treated with TAE/TACE were retrospectively studied for evaluating the safety and short-term curative effect.Results The successful rate of hemostasis was 93.8% without serious complications,but 1patient died within 1week because of continuous bleeding and hepatic function damage.Alanine transferase and aspartate transferase increased after 2to 3days′treatment（P 0.01）,but returned to pre-treatment level after 7to 10days（P〉0.05）.Total bilirubin level did not change significantly（P〉0.05）.A total of 12 patients received subsequent TACE treatment for 1to 4times during 12-month follow-up.A total of 14 patients survived after 3months.The objective effective rate was 85.7%.The survival rate was 87.5% after 3 months,75% after 6 months and 56.3% after 12 months,respectively.Conclusion The interventional treatment on senile PLC patients with rupture and bleeding proved to be safe and can improve the shortterm prognosis by effective hemostasis and delaying tumor progress.
出处
《临床荟萃》
CAS
2016年第9期994-997,共4页
Clinical Focus
关键词
肝癌
破裂
出血
化疗栓塞
介入性
liver carcinoma
ruptured
hemorrhage
chemoembolization
interventional
