摘要
卵巢早衰是由多种致病因素引起的卵巢功能衰竭性疾病,发病率呈逐年上升趋势,严重影响了女性的正常生活。坤泰胶囊由《伤寒论》中的古方化裁而来,能够有效调节女性内分泌水平、改善卵巢功能、治疗卵巢功能衰退,可单用或与性激素联合用于卵巢早衰的治疗。大鼠毒理学研究证实坤泰胶囊无明显生殖毒性,大量临床研究也表明其安全性较好。对坤泰胶囊改善卵巢早衰的动物毒理和临床研究进展进行综述,为其在临床上推广应用提供依据。
Premature ovarian failure （POF） is caused by a variety of pathogenic factors, and the morbidity of POF is increasing year by year, seriously affecting the normal life of women. Kuntai Capsule is originated from ancient traditional Chinese medicine prescriptions, and has the effect of adjusting the hormone secretion and improving the ovarian function. It could be used alone or in combination with sex hormone in the treatment of premature ovarian failure. The toxicology studies in rats demonstrated no obvious reproductive toxicity; and a large number of clinical studies have confirmed its safety. This present review summarized the clinical application of Kuntai Capsule in the treatment of patients with POF, providing a basisfor the further application of Kuntai Capsule.
出处
《药物评价研究》
CAS
2016年第4期673-676,共4页
Drug Evaluation Research
基金
河北省重大医学科研项目(No.zyzd2013018)
河北省政府资助临床医学优秀人才培养项目(No.2014571024)
河北省中医药管理局中医药科研计划课题资助项目(No.2016068)
高慧全国名老中医药专家传承工作室建设项目(No.2015048157)
关键词
和颜坤泰胶囊
卵巢早衰
毒理学
Kuntai Capsule
premature ovarian failure
toxicology studies
