摘要
研究了5(R)-(l-?氧基)-2(5H)-呋喃酮与溴代丙二酸二乙酯在无水K2CO3和相转移催化剂四丁基溴化铵(TBAB)存在下,以乙腈为溶剂,在80℃下的反应及产物结构特征.在上述条件下得到了预期的具有两个乙酯基的手性环丙烷/丁内酯衍生物3,同时还得到了含有一个乙酯基的手性环丙烷/丁内酯化合物5以及少量的含溴产物6.通过对产物结构分析,提出了产物形成的可能机理.
The reaction of 5（R）-（l-menthoxy）-2（5H）-furanone and diethyl bromomalonate was investigated in the presence of anhydrous K2CO3 and phase transfer catalyst tetrabutylammonium bromide （TBAB） using CH3CN as solvent at 80℃. In the above condition, the expected novel chiral cyclopropane/butyrolactone derivative 3 with two ethyl ester groups was obtained, and at the same time, another chiral cycloproane/butyrolactone 5 bearing only one ethyl ester group, and trace amount of bro- mo-substitued compound 6 were also obtained. The possible mechanism was proposed based on the analysis of the products.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2016年第8期1915-1920,共6页
Chinese Journal of Organic Chemistry
基金
河南省科技发展计划(No.122300410265)
洛阳师范学院2013年培育基金(No.2013-PYJJ-006)资助项目~~
