摘要
目的探讨螺内酯对难治性高血压患者RAAS指标的影响程度。方法选取2014年1月至2015年1月于我院进行治疗的58例难治性高血压患者为研究对象,将其按照随机数字法分为对照组(常规高血压治疗)29例和观察组(常规治疗加螺内酯)29例,将两组患者治疗前与治疗后1周、2周及3周的RAAS相关指标进行检测与比较。结果治疗前两组患者的RAAS相关指标均无明显差异(P>0.05);治疗后1周、2周及3周观察组的血清Ang-(1-7)均高于对照组同时间点的检测结果及本组治疗前的检测结果,其他血清相关指标均低于对照组同时间点的检测结果及本组治疗前的检测结果(P<0.05)。结论螺内酯可有效改善难治性高血压患者的RAAS相关指标水平,对高血压的治疗效果较为明显。
Objective To study and investigate the influence of spirolactone for RAAS indexes of patients with refractory hypertension. Methods Fifty eight patients with refractory hypertension in our hospital from January 2014 to January 2015 were selected as the study object, and the patients were divided into control group （conventional refractory hypertension treatment group） and observation group （conventional treatment and spirolactone group） according to the method of random number table, 29 cases in each group. Then the RAAS serum indexes of two groups before the treatment and at first, second and third week after the treatment were compared. Results The RAAS serum related indexes of two groups before the treatment had no significant differences （P〉0.05）, while the serum Ang-（1-7） of observation group at first, second and third week after the treatment were higher than those of control group at the same time and the results before the treatment, and other serum related indexes of observation group at first, second and third week after the treatment were all lower than those of control group at the same time and the results before the treatment （P〈0.05）. Conclusion The spirolactone can effectively improve the RAAS related serum indexes of patients with refractory hypertension, and its treatment effect for the hypertension is obvious.
出处
《临床医学研究与实践》
2016年第16期22-23,共2页
Clinical Research and Practice
关键词
螺内酯
难治性高血压
RAAS相关指标
spirolactone
refractory hypertension
RAAS related serum indexes
