PCI术后小剂量EPO对急性心肌梗死患者心功能、心肌损伤的影响被引量：10

Effect of small dose of EPO after PCI on cardiac function and myocardial injury in patients with acute myocardial infarction

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摘要目的:研究PCI术后小剂量促红细胞生成素(EPO)对急性心肌梗死患者心功能、心肌损伤的影响。方法:选择在我院接受经皮冠状动脉介入治疗的急性ST段抬高型心肌梗死患者86例并随机分为EPO组和对照组,术后1周时采集血清并测定心肌损伤指标、炎症反应指标、氧化应激指标、心室肌重构指标,术后6个月时进行心脏彩色多普勒超声并测定心室舒缩功能指标。结果:术后1周时,EPO组血清中LDH、CK、CK-MB、cTnI、cTnT、sCD40L、E-选择素、P-选择素、sICAM-1、MDA、O_2-、ox-LDL、PICP、CITP、PIIINP的含量显著低于对照组,GSH-Px、SOD的含量显著高于对照组,差异均具有统计学意义(P<0.05);术后6个月时,EPO组LVEF显著高于对照组,LVEDVI、LVESVI显著低于对照组,差异均具有统计学意义(P<0.05)。结论:PCI术后应用小剂量EPO能够减轻AMI患者的心肌损伤、缓解炎症反应和氧化应激反应、改善心肌重构以及心脏舒缩功能。 [ABSTRACT]Objective：To study the effect of small dose of erythropoietin （EPO）after PCI on cardiac function and myo-cardial injury in patients with acute myocardial infarction.Methods：86 cases of patients with acute ST-elevation myocardial infarction who received percutaneous coronary intervention in our hospital from April 2012 to June 201 5 were selected and ran-domly divided into EPO group and control group,serum was collected 1 week after operation to determine myocardial injury in-dexes,inflammation indexes,oxidative stress indexes and ventricular remodeling indexes,and color Doppler echocardiography was conducted 6 months after surgery to determine ventricular systolic and diastolic function indexes.Results：1 week after op-eration,serum LDH,CK,CK-MB,cTnI,cTnT,sCD40L,E-selectin,P-selectin,sICAM-1,MDA,O 2 -,ox-LDL,PICP,nbsp;CITP and PIIINP levels of EPO group were significantly lower than those of control group while GSH-Px and SOD levels were significantly higher than those of control group;6 months after operation,LVEF of EPO group was significantly higher than that of control group while LVEDVI and LVESVI were significantly lower than those of control group.Conclusion：Small dose of EPO after PCI can alleviate myocardial damage,relieve inflammation and oxidative stress,and improve myocardial remode-ling and cardiac diastolic and systolic function in patients with AMI.

作者李国民

机构地区河北省承德市围场县县医院急诊科

出处《海南医学院学报》 CAS 2016年第17期1969-1972,共4页 Journal of Hainan Medical University

基金河北省科学技术厅计划项目(135209)~~

关键词急性心肌梗死经皮冠状动脉介入治疗促红细胞生成素炎症反应氧化应激反应 Acute myocardial infarction Percutaneous coronary intervention Erythropoietin Inflammation Oxida-tive stress

分类号 R542.22 [医药卫生—心血管疾病]

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