摘要
目的探讨糖皮质激素联合阿奇霉素治疗肺炎支原体感染性大叶性肺炎患儿的临床效果。方法选取2015年1-11月东莞市石碣医院收治的30例肺炎支原体感染性大叶性肺炎患儿作为研究对象,采用随机数字表法将其分为试验组(17例)和对照组(13例)。在抗炎退热和镇咳平喘常规治疗基础上,对照组患儿予以阿奇霉素,试验组患儿采用阿奇霉素联合糖皮质激素进行治疗,用药治疗1个疗程后比较两组患儿X线胸片影像学检查结果、临床综合指标、炎性因子水平。结果治疗后,观察组患儿肺部阴影治愈率明显高于对照组,差异有统计学意义(P<0.05);两组患儿的血清C反应蛋白(CRP)、红细胞沉降率(ESR)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平均明显降低,试验组相关炎性因子指标均明显低于对照组,差异均有统计学意义(均P<0.05);试验组患儿发热消退时间、咳嗽持续时间、啰音消失时间、X线胸片恢复正常时间及住院时间均明显短于对照组,差异均有统计学意义(均P<0.05)。结论糖皮质激素辅助治疗肺炎支原体感染性大叶性肺炎患儿临床效果显著,不仅能有效减轻炎性反应,同时利于患儿早日恢复。
Objective To investigate the clinical effect of glucocorticoid combined with azithromycin infection of lobar pneumonia mycoplasma pneumonia treatment.Methods Select the January to November 2015 Dongguan Shijie hospital treated 30 cases of mycoplasma pneumonia infection lobar pneumonia in children as the research object,using the random number table method divided into experimental group（17 cases） and control group（13 cases）.In the anti-inflammatory and antipyretic and antitussive and antiasthmatic on the basis of routine treatment,the control group of patients treated with azithromycin,the children in the experimental group with Azithromycin combined with glucocorticoid treatment,after treatment of one course of treatment in treatment of the two groups were compared with X-ray imaging findings,clinical comprehensive index,inflammatory factor levels.Results Returned to normal after treatment,the observation group of patients with lung shadows cure rate was significantly higher than that in the control group,the difference was statistically significant（P〈0.05）.After the treatment,the two groups of children serum C-reactive protein（CRP）,erythrocyte sedimentation rate（ESR） and interleukin 6（IL-6）,interleukin-8（IL-8） levels were significantly lower,the test group of related inflammatory factors were significantly lower than those of the control group,the differences were statistically significant（P〈0.05）;the experimental group of children with fever subsided time, persistent cough time,rales disappearance time,X-ray time and hospital stay were significantly shorter than the control group,the differences were statistically significant（P〈0.05）.Conclusion Glucocorticosteroid in the treatment of mycoplasma infection of lobar pneumonia clinical effect significantly,not only can effectively relieve the inflamematory reaction,also help children with early recovery.
出处
《中国药物经济学》
2016年第8期22-24,共3页
China Journal of Pharmaceutical Economics
关键词
糖皮质激素
阿奇霉素
大叶性肺炎
支原体感染
Glucocorticoid hormone
Azithromycin
Lobar pneumonia
Mycoplasma infection
