摘要
目的探讨肝硬化伴全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)患者血清C反应蛋白(C-reaction protein,CRP)、降钙素原(procalcitonin,PCT)、白细胞介素-6(interleukin-6,IL-6)的变化趋势及其意义。方法选取本院2012年1月至2015年12月收治的76例肝硬化伴SIRS患者进行回顾性分析,其中治疗后病情好转出院54例(好转组)、死亡22例(死亡组),对两组患者确诊SIRS后不同时间点的血清CRP、PCT、IL-6等指标进行监测,并进行对比分析。结果好转组和死亡组患者在SIRS诊断第1天的CRP、PCT和IL-6的水平差异无显著性(P>0.05),SIRS确诊第3天、第7天死亡组患者的CRP、PCT和IL-6水平均显著高于好转组(P<0.05);好转组患者CRP、PCT和IL-6呈逐渐降低的趋势(P<0.05),死亡组患者的CRP、PCT和IL-6水平在第3天、第7天较第1天变化不显著(P>0.05)。死亡组患者的APACHEⅡ评分与CRP、PCT及IL-6水平均呈显著的正相关关系(P<0.05)。结论肝硬化伴SIRS患者CRP、PCT及IL-6持续高水平提示患者预后不良。
Objective To investigate the changes of serum C-reaction protein（CRP）, procalcitonin（PCT） and interleukin-6（IL-6） in patients with cirrhosis and systemic inflammatory response syndrome（SIRS） and its significance. Method 76 cases of liver cirrhosis patients with SIRS were analyzed retrospectively which were selected in our hospital from January 2012 to December 2015. After treatment, 54 cases（improvement group） and 22 cases of death（death group） were improved after treatment, the serum levels of CRP, PCT, IL-6 and other indicators of two groups of patients with SIRS after different time points were monitored and compared. Result There was no significant difference in the level of CRP, PCT and SIRS between the improvement group and the death group at first days after IL-6 diagnosis（P〉0.05）, SIRS diagnosed on day 3, day 7, the group of death in patients with CRP, PCT and IL-6 levels were significantly higher than the improved group（P〈0.05）; CRP, PCT and IL-6 showed a gradually decreasing trend in the improvement group（P〈0.05）, the levels of CRP, PCT and IL-6 in the death group were not significant at third days, seventh days with first day（P〉0.05）. The death group of patients with APACHE score and CRP, PCT and IL-6 levels were significantly positively correlated（P〈0.05）. Conclusion Persistent high levels of CRP, PCT, and IL-6 in patients with cirrhosis and SIRS were associated with poor prognosis.
出处
《中国医刊》
CAS
2016年第9期52-55,共4页
Chinese Journal of Medicine
