摘要
造血干细胞移植是重型再生障碍性贫血(急性"髓劳")的重要治疗手段之一,中医药在促进植入、刺激造血、调节免疫等方面具有重要的意义,近年来被不断实践应用。文章结合古籍、文献及临床实践经验对干细胞移植的整个过程进行了中医理论阐述,认为"髓劳"即"精髓劳伤",本于肾元亏虚。"移植物"按功能不同可分为"髓阴""髓阳",造血干细胞移植即为直补"精髓"的过程,"髓阴""髓阳"的交互生化以及制约权衡决定了移植物抗宿主病的发生与否及严重程度。结合移植过程中气阴两虚-阴阳两虚-脾肾阳虚的证侯演变特点,分期论治的同时贯穿"痰瘀同治"是可行的治疗方案。
Recently,traditional Chinese medicine（TCM） has played important roles in the process of hematopoietic stem cell transplantation（HSCT）,one of important therapeutic program in acute aplastic anemia,especially in transplantation,hematopoiesis and immune regulation.This article is mainly on explaining the TCM theory during the process of SCT.‘Suilao＇ means the exhaustion of marrow,which attributes to the dei ciency of kidney.‘Graft＇ could be divided in to ‘Suiyin＇ and ‘Suiyang＇ according to the function under the theory of TCM.Transplantation means to reinforce the marrow,and the interaction and interlimitation of ‘Suiyin＇ and ‘Suiyang＇ determines the incidence and severity of graft versus host disease（GVHD）.Combined with the characteristic of sydrome evolution from dei ciency of both qi and yin to dei ciency of both yin and yang to yan dei ciency of spleen and kidney,the treatment based on stage differentiation and ‘removing phlegm and blood-stasis＇ according the syndrome evolution characteristics may the feasible protocol.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第9期3457-3460,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局中医药行业科研专项资助项目(No.201107001,No.201407001)
国家中医临床研究基地业务建设科研专项资助项目(No.JDZX2012178)
浙江省中医药科学研究基金项目(No.2016ZA069)~~
关键词
再生障碍性贫血
髓劳
造血干细胞移植
中医内涵
Aplastic anemia
Suilao
Hematopoietic stem cell transplantation
Connotation in TCM
