摘要
目的研究冠心病患者血清鸢尾素(irisin)水平与冠状动脉病变严重程度的相关性,探讨irisin对冠状动脉病变评估的意义。方法选取行冠状动脉造影检查的冠心病患者106例为研究对象,分为冠脉正常组(n=34)和冠脉病变组(n=72),根据冠状动脉病变范围进一步分为单支病变组(n=30)、双支病变组(n=26)、多支病变组(n=16)。根据冠脉造影结果,计算Gensini评分。采用ELISA法检测血清irisin水平,分析irisin与冠状动脉病变程度的相关性。结果冠脉病变组血清irisin水平显著低于冠状动脉正常组(P<0.01);冠状动脉病变组各亚组之间比较,与单支病变组比较,双支病变组、多支病变组Gensini评分逐渐增高(P<0.05或0.01),且C组显著高于B组(P<0.05);与A组比较,B组、C组血清irisin水平均显著下降(P<0.05或0.01),且多支病变组显著低于双支病变组(P<0.01)。相关性分析显示,irisin水平与冠状动脉Gensini评分、血糖水平呈负相关(r=-0.438,r=-0.525,均P<0.05)。Logistic回归分析显示,血清尿酸、irisin是冠状动脉病变的独立危险因素。结论冠状动脉病变的发生可能与血清irisin水平降低有关,是预测冠心病发生的独立危险因素之一。
Objective To explore the relationship between the level of serum irisin and the severtiy of coronary artery lesions in patients with coronary heart disease（CHD）, and explore the significance of serum irisin in evaluation of coronary artery lesions. Methods 106 patients with coronary heart disease were enrolled for the study and underwent coronary angiography. The patients were divided into four groups：normal coronary artery group （ n=34） and coronary artery disease group （ n=72） . According to the results of coronary artery lesion, patients were further divided into only a single coronary artery disease group （ n=30, group A） , double coro-nary artery disease group （ n=26, group B ） , more than two coronary artery disease group（ n=16,group C ） . According to the results of coronary angiography, the Gensini score was calculated. Serum irisin level was detected by ELISA method. The correlation of serum Irisin with the severity of coronary artery lesions was analyzed. Results The level of serum Irisin in coronary artery disease group was significantly lower than that of normal coronary artery group（P〈0.01）. Compared with group A, Gensini socre was significantly in-creased in group B and group C （ P〈0.05 or 0.01） . Compared with group B, Gensini socre was significantly increased in group C （ P〈0.05）. Compared with group A, the level of serum irisin was significantly reduced in group B and group C （P〈0.05 or 0.01）. Com-pared with group B, the level of serum irisin was significantly reduced in group C （P〈0.01）. Correlation analyses showed a negative correlation between serum irisin and Gensini scores, FBG （ respectively r=-0.438, r=-0.525, all P〈0.05）;Logistic regression ana-lyses showed that UA and irisin were associated independently with coronary artery lesion. Conclusion The development of coronary artery leision may be related with declined level of serum irisin, and it’ s an important biochemical indicator reflecting the severity of coronary heart disease.
出处
《东南国防医药》
2016年第4期382-384,共3页
Military Medical Journal of Southeast China
