摘要
目的探讨硫普罗宁针剂治疗慢性病毒性肝炎的临床有效性及安全性情况。方法选取本院2015年1月～2016年1月收治的慢性病毒性肝炎患者124例，随机分成对照组、观察组各62例，对照组给予常规临床治疗，观察组在对照组基础上联合硫普罗宁针剂治疗，比较两组患者的有效性、安全性情况。结果两组患者在治疗前ALT、AST、TBIL指标间均无统计学差异（P〉0．05），治疗后两组患者各项肝功能指标均显著改善，但观察组较对照组数据均具显著性差异；观察组临床疗效优良率91．94％显著高于对照组的79．03％，两组数据间差异具有显著性；观察组治疗结束14例HBeAg转阴，转阴率为22．58％，对照组转阴1例，转阴率为1．61％，观察组血清肝炎病毒转阴率显著高于对照组。结论在常规治疗基础上给予慢性病毒性肝炎患者联合硫普罗宁针剂治疗，可显著改善患者肝功能相关指标，提高疗效优良率，且具有安全性高的特点，值得临床推广使用。
Objective To explore the clinical effectiveness and safety of Tiopronin injection in treatment of chronic viral hepatitis. Methods 124 cases of patients with chronic viral hepatitis cured in our hospital from January 2015 to January 2016 were divided into control group and observation group with 62 cases in each. Patients in the control group were treated with conventional clinical therapy. Patients in the observation group were treated with Tiopronin injection on the basis of conventional clinical therapy. The effectiveness and safety of patients of the two groups were compared. Results Before the treatment, there was no significant difference between ALT, AST and TBIL indexes of the two groups （P 〉 0.05）. After the treatment, all liver function indexes of the two groups were significantly improved. But compared with the control group, the data of the observation group were significantly different. The clinical curative effect excellent rate of the observation group was 91.94%, which was significantly higher than that of the control group with 79.03%. There was significant difference between the two groups. In the observation group, the HBeAg turned to be native with 14 cases after the treatment, and the rate was 22.58%. In the control group, the HBeAg turned to be native with 1 case only after the treatment, and the rate was 1.61%. So the negative rate of serum hepatitis virus of the observation group was significantly higher than that of the control group. Conclusion The method of Tiopronin injection on the basis of conventional clinical therapy in treatment of patients with chronic viral hepatitis could significantly improve liver function indexes of the patients, and improve the curative effect of excellent rate. And it had high security features. It was worthy of clinical popularization and application.
出处
《中国医药科学》
2016年第15期74-76,共3页
China Medicine And Pharmacy
