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术中唤醒麻醉技术下的脑功能区胶质瘤继发癫痫切除术疗效分析

Discussion on the Anti-depression Target of TCM Herbs Based on Neurovascular Unit
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摘要 目的分析术中唤醒麻醉技术下的脑功能区胶质瘤继发癫痫切除术的疗效。方法:选取60例脑功能区胶质瘤继发癫痫患者,采用了核磁共振成像进行扫描,了解肿瘤的位置,DTT了解白质纤维束和肿瘤位置之间的关系,Bold—fMRI定位脑部运动功能区,进行手术入路设计以及肿瘤的切除范围,患者接受了全麻,唤醒,再一次全麻;术中采用B超和皮层脑电图进行定位脑部肿瘤区和癫痫区,在显微镜的观察下进行肿瘤的切除。结果:31例患者运动区肿瘤唤醒后拔出喉罩,进行了运动区定位以及功能测试之后,再为患者置入喉罩全麻;22例患者语言区肿瘤唤醒后拔出喉罩,进行了语言区定位以及功能测试之后,再为患者置入喉罩全麻;另有7例患者因为唤醒时变得烦躁、憋气,患者的脑部组组膨出十分明显,放弃唤醒,未进行定位以及功能测试全麻。手术的过程中,用神经电生理监测定位脑部功能区阳性42例,18例患者皮层功能定位阴性,皮层脑电图监测中,发现了瘤周皮层致癫痫的病灶46例。在手术后,53例患者癫痫发作完全消失,17例患者癫痫发作的次数减少。结论:通Bold—fMRI和DTT,能够更加清晰的了解到患者的脑部肿瘤与功能区的位置关系和毗邻白质束的推移状态、浸润状态、破坏状态,有助于医师设计出适合患者的手术入路和肿瘤切除范围,能够保护患者脑部未受侵害的纤维束,临床效果十分显著,减低了手术的风险。 This paper aims to investigate the TCMintervention in the imbalance of neurovascular unit (NVU)homeostasis in de-pression patients.Through the analysis of the pathogenesis of homeostasis changes of the NVU in depression and combination of TCMtheory and modern medical researches,this paper proposed the general intervention ideas:simultaneous treatment of qi and blood,simultaneous consideration of both nerves and blood vessels and benefiting the original qi and relieving stagnation then target to the NVU.Focused on the key links of the NVU homeostasis changes in depression,this paper suggested to tonify qi and reduce phlegm to treat depression,adjust the blood brain barrier to maintain the NVU micro-environment,reinforce the vital essence and activate blood to treat depression,build the neural vascular coupling to reconstruct NVU basic structure,consolidate the constitution and detoxicate to relieve depression,resist nerve inflammation to protect the NVU components.In conclusion,the target to the NVU should sufficiently manifest the principle of the holistic and differential treatment of TCM.
出处 《世界中医药》 CAS 2016年第B06期1632-1633,共2页 World Chinese Medicine
基金 国家自然科学基金项目(编号:81573790 81072801) 北京市科技计划(编号:Z141100002214014、Z161100001816013) 中央级公益性科研院所基本科研业务费专项(编号:ZZ0708076)
关键词 唤醒麻醉技术 脑功能区胶质瘤继发癫痫 临床效果 切除手术 Depression Neurovascular unit TCMtherapy
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