摘要
目的观察感染性肺炎新生儿体液免疫与细胞免疫的变化,为其诊断治疗提供依据。方法选取2013年10月-2015年10月医院治疗的37例感染性肺炎新生儿为观察组,另选同时期的37名健康新生儿为对照组,对比分析两组新生儿的体液免疫与细胞免疫指标水平,并比较观察组轻、重症与急性期、恢复期的检测结果。结果观察组新生儿的细胞免疫指标CD3+、CD4+及CD4/CD8水平分别为(52.12±4.03)%、(31.22±3.15)%和1.24±0.11,均低于对照组的(59.63±4.55)%、(37.86±3.59)%、1.24±0.11;CD8+水平为(21.01±2.23)%,高于对照组的(21.01±2.23)%,其他细胞免疫指标及体液免疫指标均低于对照组,重症患儿低于轻症患儿,急性期患儿低于恢复期患儿,差异均有统计学意义(P<0.05)。结论新生儿感染性肺炎体液与细胞免疫呈现明显的异常,疾病的严重程度与疾病不同阶段期对于免疫状态的影响均较大,应加强对该类患儿免疫状态的调控。
OBJECTIVE To observe the changes of humoral immunity and cellular immunity of neonates with infectious pneumonia so as to provide guidance for clinical diagnosis and treatment.METHODS Totally 37 neonates with infectious pneumonia who were treated in the hospital from Oct 2013 to Oct 2015 were chosen as the observation group,meanwhile,37 healthy neonates were set as the control group.The humoral immunity indexes and cellular immunity indexes were analyzed and compared between the two groups of neonates,and the test results were observed and compared between the neonates with mild infectious pneumonia and the neonates with severe infectious pneumonia as well as between the neonates with infectious pneumonia in acute phase and the neonates with infectious pneumonia in recovery phase.RESULTS As compared with the cellular immunity indexes,the CD3＋level of the observation group was（52.12±4.03）%,lower than（59.63±4.55）% of the control group;the CD4＋level of the observation group was（31.22±3.15）%,lower than（37.86±3.59）% of the control group;the CD4/CD8 level of the observation group was 1.24±0.11,lower than 1.24±0.11 of the control group.The CD8＋level of the observation group was（21.01±2.23）%,higher than（21.01±2.23）% of the control group;the rest of the cellular immunity indexes and humoral immunity indexes were lower in the observation group than in the control group,which were lower in the children with severe infectious pneumonia than in the neonates with mild infectious pneumonia and were lower in the neonates with acute phase of infectious pneumonia than in the neonates with recovery phase of infectious pneumonia（P〈0.05）.CONCLUSION The neonates with infectious pneumonia present with remarkable abnormal humoral immunity and cellular immunity,and the severity of disease and disease in different phases have significant impact on the immune state;it is necessary to strengthen the regulation of immune state of such group of neonates.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第17期4058-4060,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(81370930)
绍兴市科技局科技计划基金资助项目(绍市科2013-101)
关键词
新生儿感染性肺炎
体液免疫
细胞免疫
Neonate with infectious pneumonia
Humoral immunity
Cellular immunity
