摘要
目的探讨血清基质细胞衍生因子-1(SDF-1)在糖尿病视网膜病变中的检测意义及与血管内皮生长因子(VEGF)及相关代谢指标的关系。方法收集50例健康者和124例糖尿病患者,其中58例为糖尿病视网膜病变患者(DR组),66例为糖尿病无视网膜病变患者(NDR组),采集血清检测相关生化指标及血清中SDF-1及VEGF的水平。结果 DR组中SDF-1、VEGF明显升高,与NDR组及对照组比较均差异有统计学意义(P<0.05),NDR组中SDF-1、VEGF浓度也较对照组明显升高(P<0.05);SDF-1与VEGF、空腹血糖、甘油三酯、尿微量白蛋白及胱抑素C呈正相关性(P<0.05),而与糖化血红蛋白无相关性。结论血清SDF-1与糖尿病视网膜病变的发生发展有密切关系。
Objective To explore the significance of serum stromal cell derived factor - 1 （ SDF - 1 ） concentration levels in diabetic retinopathy and research the relationship of SDF- t with vascular endothelial growth factor （VEGF） and related metabolic in- dex. Methods 50 healthy subjects and 124 cases with type 2 diabetes mellitus were included in the study,the patients were then divided into NDR group （ n = 66） and DR group （ n = 58）, serum levels of VEGF, SDF - 1 and related metabolic index of each group were detec- ted. Results The serum level of SDF - 1 and VEGF in DR group was elevated with NDR group and the healthy control group respective- ly （ P 〈 0. 05 ）, it also was elevated in NDR group compared with healthy control group （ P 〈 0.05 ）. SDF - 1 had a positive correlation with VEGF, FPG,TG, CysC, MA,and had no correlation with HbAlc. Conclusion Serum level of SDF - 1 has a close relation with de- velopment of diabetic retinopathy.
出处
《宁夏医学杂志》
CAS
2016年第9期781-783,共3页
Ningxia Medical Journal
基金
宁夏自然科学基金资助项目(NZ14159)
