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盐酸西替利嗪联合普拉洛芬治疗儿童春季角结膜炎的疗效及依从性 被引量:9

Effect and compliance of cetirizine hydrochloride and pranoprofen eye drops on children with vernal keratoconjunctivitis
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摘要 目的:观察盐酸西替利嗪滴剂联合普拉洛芬滴眼液治疗儿童春季角结膜炎的疗效及依从性。方法:收集2014-01/2015-12到我院眼科门诊就诊,诊断为双眼春季角结膜炎的63例儿童患者,按照随机数字表法将患儿分为试验组和对照组,试验组给予盐酸西替利嗪滴剂联合1g/L普拉洛芬滴眼液进行治疗,盐酸西替利嗪滴剂2次/d,每次5滴(0.25mL,2.5mg,≤6岁)或每次10滴(0.5mL,5mg,〉6岁),直接口服或加入饮料食物中服用;1g/L普拉洛芬滴眼液4次/d,1滴/次,点眼;对照组仅给予盐酸西替利嗪滴剂进行治疗,2次/d,每次5滴(0.25mL,2.5mg,≤6岁)或每次10滴(0.5mL,5mg,〉6岁),直接口服或加入饮料食物中服用。疗程共14d。记录患儿用药前后的症状和体征、用药依从性和药物不良反应情况,并对用药前后的症状及体征进行评分并比较。结果:两组患儿治疗后的症状、体征及总体评分均有明显改善,差异有统计学意义(t_(试验组症状)=10.41,P〈0.05;t_(试验组体征)=10.05,P〈0.05;t试验组总体=10.75,P〈0.05;t_(对照组症状)=8.11,P〈0.05;t_(对照组体征)=8.89,P〈0.05;t_(对照组总体)=8.41,P〈0.05);试验组治疗后症状、体征和总体评分低于对照组,差异有统计学意义(t_(症状)=5.27,P〈0.05;t_(体征)=3.97,P〈0.05;t_(总体)=4.32,P〈0.05);试验组有效率(85%)显著高于对照组有效率(60%),差异有统计学意义(χ^2=4.92,P〈0.05);94%的患儿依从性良好;未见患儿出现困倦及口干等不良反应。结论:盐酸西替利嗪滴剂联合普拉洛芬滴眼液对于治疗儿童春季角结膜炎具有显著疗效及良好的依从性,明显提高治疗的有效率,且无明显不良反应,安全性高。 AIM: To observe the efficacy and compliance of cetirizine hydrochloride and pranoprofen eye drops on children with vernal keratoconjunctivitis. ● METHODS: A total of 63 children with vernal keratoconjunctivitis, from the outpatient department in our hospital between Jan. 2014 and Dec. 2015, were randomly divided into two groups including experimental group and control group. The cases in experimental group were treated with cetirizine hydrochloride, 2 times/d, 5 drops (0. 25ml, 2. 5mg) each time (≤6 years) or 10 drops (0. 5ml, 5mg) each time (〉6 years), oral or oral with beverage and food, 1g/L pranoprofen eye drops, 4 times/d, 1 drop each time. The cases in control group were only treated with cetirizine hydrochloride, 2 times /d, 5 drops (0. 25ml, 2. 5mg) each time (≤6 years) or 10 drops (0. 5ml, 5mg) each time (〉6 years), oral or oral with beverage and food for 14d. All the children were detected the scores of symptom and pathology before and after treatment. Compliance and side effect of the drug were surveyed by questionnaire. ● RESULTS: The scores of symptom, pathology and overall total after treatment were significantly lower than those before treatment in each group ( texperimental, symptom =10. 41, P 〈 0. 05; texperimental, pathology = 10. 05, P 〈 0. 05;texperimental, overal =10. 75, P〈0. 05;tcontrol, symptom=8. 11, P〈0. 05;tcontrol, pathology=8. 89, P〈0. 05; tcontrol, overal =8. 41, P〈0. 05). The scores of symptom, pathology and overall total in experimental group were lower than those in control group after the treatment (tsymptom=5. 27, P〈0. 05; tpathology=3. 97, P〈0. 05;toveral =4. 32, P〈0. 05). The effective rate of experimental group ( 85%) was significantly higher than control group (60%) (χ^2 =4. 92, P〈0. 05). Most of the children ( 94%) had very good compliance. None of children had side effect such as sleepiness and thirst. ● CONCLUSION: Cetirizine hydrochloride and pranoprofen eye drops in combination may offer a safety and effective treatment on children with vernal keratoconjunctivitis and have good compliance.
作者 刘明 陈珺
出处 《国际眼科杂志》 CAS 2016年第10期1898-1901,共4页 International Eye Science
关键词 儿童 春季角结膜炎 盐酸西替利嗪滴剂 普拉洛芬滴眼液 children vernal keratoconjunctivitis cetirizine hydrochloride pranoprofen
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参考文献15

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