摘要
目的:观察熄风震颤方药联合吡贝地尔治疗早中期帕金森病的webster总评分、相关因子评分以及中医证候的变化。方法:将帕金森患者80例随机数字分为治疗组与对照组各40例,对照组采用吡贝地尔进行治疗,治疗组采用熄风震颤方药联合吡贝地尔治疗。结果:治疗组有效率77.5%,对照组有效率52.5%。两组有效率比较有显著差异(P<0.05)。经过中医证候疗效比较,治疗组改善率为100.0%,对照组改善率为2.5%,两组比较,有显著性差异(P<0.01)。治疗组webster评分提示治疗4周后与治疗前比较无改善(P>0.05),至第8周、第12周时与治疗前比较有改善,差异有统计学意义(P<0.01)。对照组webster评分治疗后4周与治疗前比较无改善(P>0.05),治疗后8周与治疗后4周比较有改善,但无显著差异(P>0.05);治疗后12周与治疗后8周比较Webster总评分下降有显著差异(P<0.01)。中医证候分析提示治疗组治疗后4周、8周、12周的评分与治疗前相比,均有明显改善,差异有统计学意义(P<0.01)。对照组在治疗4周、8周、12周后的中医证候评分与治疗前相比,治疗后中医证候评分较治疗前略有增加。结论:熄风震颤方药联合吡贝地尔治疗早中期帕金森病疗效明显,有较为明显的增效减毒作用,同时对于患者神经功能恢复、临床症状改善以及生活能力提高效果理想。
Objective ： To observe webster total score and relevant factor score and TCM syndrome changes of Xifeng Zhenchan prescription combined piribedil treatment of early and medium stage Parkinson disease. Methods ： 80 cases of patients with Parkinson were randomly divided into the treatment group and the control group with 40 cases in each group. The control group was given Piribedil, and treatment group was treated with Xifeng Zhenchan prescription combined Piribedil. Results：The effective rate of treatment group 77.5%, and the control group was 52.5%, and the difference was statistically significant （ P 〈 0. 05 ）. Through the comparison of TCM syndrome, improvement rate of the treatment group was 100.0%, and the control group was 2.5%, and there was significant difference between two groups （P 〈 0.01 ）. The webster score of treatment group prompted that there was no improvement between 4 weeks after treatment compared with before treatment, to the eighth week, and the twelfth week, the difference was statistically significant compared with before treatment （P 〈 0.01 ）. TCM syndrome analysis showed that the scores 4 weeks ,8 weeks and 12 weeks after treatment compared with before treatment had significantly improved, the difference was statistically significant （P 〈 0. 01 ）. The control group TCM syndrome score 4 weeks,8 weeks, 12 weeks after treatment increased slightly compared with before treatment. Conclusion：Xifeng Zhenchan prescription combined Piribedil on early and medium stage Parkinson disease has obvious curative effect, and synergistic and attenuated effect is more obvious, at the same time the ideal effect for the recovery of neurological function, clinical symptoms and living ability improvement.
出处
《中医学报》
CAS
2016年第8期1189-1191,共3页
Acta Chinese Medicine
关键词
帕金森病
熄风震颤方药
中医证候
中医药治疗
Parkinson＇s disease
Xifeng Zhenchan prescription
TCM syndrome
traditional Chinese medicine therapy
