摘要
目的探讨血清RANKL的表达水平与2型糖尿病合并恶性肿瘤的关系.方法采用 ELISA方法检测正常健康人、2 型糖尿病和合并恶性肿瘤患者血清中RANKL的表达水平.应用单因素方差分析进行统计学分析,以a=0.05为标准.结果2型糖尿病合并恶性肿瘤患者血清RANKL为618.14±12.87pmol/L,2型糖尿病患者RANKL525.56±35.15pmol/L,正常人结果为411.98±8.77pmol/L .单因素方差分析结果,2型糖尿病患者血清RANKL 表达高于正常健康人,比较有统计学意义 （F=14.88,P=0.0014〈0.05）.合并恶性肿瘤患者血清RANKL 表达高于2型糖尿病患者,同样也有统计学意义（F=5.83,P=0.028〈0.05）.结论血清RANKL表达水平的提高可能预测2 型糖尿病患者发生恶性肿瘤的几率增高.
ObjectiveTo investigate the relationship between serum RANKL expression level and type 2 diabetes mellitus complicated with malignant tumor.MethodsELISA method was used to detect the expression of RANKL in the serum of normal healthy people, patients with type 2 diabetes mellitus and complicated with malignant tumor. The statistical analysis was performed with one factor analysis of variance, and the a=0.05 was used as the standard.Resultstype 2 diabetes merger of RANKL in serum of patients with malignant tumor 618.14 （12.87pmol/L and type 2 diabetic patients RANKL525.56 （35.15pmol/L and normal results for 411.98 （8.77pmol/L. Single factor variance analysis results. In type 2 diabetic patients serum RANKL expression is higher than that of normal people, compared with statistical significance （F=14.88, P = 0.0014 〈 0.05）. Was higher than that in patients with type 2 diabetes mellitus complicated RANKL in serum of patients with malignant tumor, also have statistical significance （F=5.83, P=0.028 〈 0.05）. Conclusion the increase in the expression of RANKL in serum may predict the increased risk of malignancy in patients with type 2 diabetes mellitus.
出处
《湖南中医药大学学报》
CAS
2016年第A01期487-488,共2页
Journal of Hunan University of Chinese Medicine
