摘要
目的:观察小牛血清去蛋白注射液辅助治疗急性前循环脑梗死的近期疗效和安全性。方法:采用随机、单盲、对照设计,96例患者随机分为对照组和观察组各48例,在常规治疗的基础上,分别静滴0.9%氯化钠注射液或小牛血清去蛋白注射液,连续21 d。分别采用美国国立卫生研究院卒中量表(NIHSS)、Barthel指数(BI)、改良Rankin量表(mRS)评价临床神经功能缺损、日常生活能力及预后功能残疾水平,记录药品不良反应。结果:治疗21 d后,两组患者NIHSS、BI及mRS评分均较治疗前有明显改善(P<0.05),且观察组上述指标改善明显优于对照组(P<0.05)。观察组临床总有效率为81.3%,明显高于对照组的62.5%(P<0.05)。用药前后两组患者血尿常规、肝肾功能、心电图等检查无异常变化,未见与小牛血清去蛋白注射液相关的不良事件。结论:小牛血清去蛋白注射液辅助治疗,对急性前循环脑梗死具有较好的治疗作用。
Objective：To evaluate the short-term therapeutic efficacy and safety of deproteinised calf serum injection adjuvant therapy of in patients with acute anterior circulation cerebral infarction. Methods： Ninety-six patients with acute anterior circulation cerebral infarction were enrolled in the randomized single-blind control trial. They were randomly divided into control group and treatment group, and 48 cases in each group. They were both treated by identical basis therapy, the control group received physiological saline, the treatment group received deproteinised calf serum injection additionally for 21 consecutive days. National Institute of Health Stroke Scale score （NIHSS）, Barthel index （BI） and modified Rankin scale （mRS） were calculated to assess the neurological function impairment, activity of daily living and extent of disability in prognosis, respectively ; the adverse reactions were recorded. Results ： After 21 days＇ treatment, the NIHSS score, mRS score, and BI score were siginifieantly improved in both two groups （ P 〈 0.05 ）. As compared with those in control group, the above indexs were significantly reduced in the treatment group （P 〈 0.05 ）. The clinical efficiency was 81.3% in the treatment group, which was higher than 62.5% of control group. No abnormal changes of blood routine examinations, rinalysis, hepatorenal function and ECG, no drug relative adverse reactions was noted either. Conclusion：The adjuvant therapy of deproteinised calf serum injection could improve the clinical outcomes of patients with acute anterior circulation cerebral infarction.
出处
《药物流行病学杂志》
CAS
2016年第9期541-543,共3页
Chinese Journal of Pharmacoepidemiology
关键词
小牛血清去蛋白注射液
脑梗死
疗效
安全性
Deproteinised calf serum injection
Cerebral infarction
Clinical efficacy
Safety
